Citrus aurantium Naringenin Prevents Osteosarcoma Progression and Recurrence in the Patients Who Underwent Osteosarcoma Surgery by Improving Antioxidant Capability

被引:27
作者
Zhang, Lirong [1 ]
Xu, Xiaohua [2 ]
Jiang, Tiechao [3 ]
Wu, Kunzhe [4 ]
Ding, Chuanbo [5 ]
Liu, Zhen [6 ]
Zhang, Xuanhe [7 ]
Yu, Tianhua [8 ]
Song, Changlong [9 ]
机构
[1] Jilin Univ, Dept Pathol, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
[2] Jilin Univ, Dept Nephrol, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
[3] Jilin Univ, Cardiol Dept, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
[4] China Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 4, Shenyang 110032, Liaoning, Peoples R China
[5] Jilin Agr Univ, Coll Chinese Med Mat, Teaching Off, Changchun 130118, Jilin, Peoples R China
[6] Liuhe Dist Hosp Nanjing, Pediat, Nanjing 211500, Jiangsu, Peoples R China
[7] Shihezi Univ, Shihezi 832003, Peoples R China
[8] Jilin Univ, Blood Transfus Dept, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
[9] Jilin Univ, Breast Surg Dept, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China
关键词
CAROTENE CANCER PREVENTION; CELL-CYCLE ARREST; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; BREAST-CANCER; FLAVONOIDS HESPERIDIN; SIGNALING PATHWAYS; GROWTH-INHIBITION; COLON-CANCER; FOLLOW-UP;
D O I
10.1155/2018/8713263
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Citrus aurantium is rich in flavonoids, which may prevent osteosarcoma progression, but its related molecular mechanism remains unclear. Flavonoids were extracted from C. aurantium and purified by reparative HPLC. Each fraction was identified by using electrospray ionisation mass spectrometry (ESI-MS). Three main components (naringin, naringenin, and hesperetin) were isolated from C. aurantium. Naringenin inhibited the growth of MG-63 cells, whereas naringin and hesperetin had no inhibitory function on cell growth. ROS production was increased in naringin-and hesperetin-treated groups after one day of culture while the level was always lowest in the naringenin-treated group after three days of culture. 95 osteosarcoma patients who underwent surgery were assigned into two groups: naringenin group (NG, received 20 mg naringenin daily, n = 47) and control group (CG, received 20 mg placebo daily, n = 48). After an average of two-year follow-up, osteosarcoma volumes were smaller in the NG group than in the CG group (P > 0.01). The rate of osteosarcoma recurrence was also lower in the NG group than in CG group. ROS levels were lower in the NG group than in the CG group. Thus, naringenin from Citrus aurantium inhibits osteosarcoma progression and local recurrence in the patients who underwent osteosarcoma surgery by improving antioxidant capability.
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页数:16
相关论文
共 55 条
[21]   Liquid chromatographic-photodiode array mass spectrometric analysis of dietary phytoestrogens from human urine and blood [J].
Franke, AA ;
Custer, LJ ;
Wilkens, LR ;
Le Marchand, L ;
Nomura, AMY ;
Goodman, MT ;
Kolonel, LN .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2002, 777 (1-2) :45-59
[22]   Anti-oxidative effect of AST-120 on kidney injury after myocardial infarction [J].
Fujii, Hideki ;
Yonekura, Yuriko ;
Yamashita, Yusuke ;
Kono, Keiji ;
Nakai, Kentaro ;
Goto, Shunsuke ;
Sugano, Mikio ;
Goto, Sumie ;
Fujieda, Ayako ;
Ito, Yoshiharu ;
Nishi, Shinichi .
BRITISH JOURNAL OF PHARMACOLOGY, 2016, 173 (08) :1302-1313
[23]   Gastric Cancer: Epidemiologic Aspects [J].
Gonzalez, Carlos A. ;
Sala, Nuria ;
Rokkas, Theodore .
HELICOBACTER, 2013, 18 :34-38
[24]   Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk [J].
He, Yu ;
Liang, XinJun ;
Meng, ChunQing ;
Shao, ZengWu ;
Gao, Yong ;
Wu, Qiang ;
Liu, JianXiang ;
Wang, Hong ;
Yang, ShuHua .
INTERNATIONAL ORTHOPAEDICS, 2014, 38 (08) :1671-1676
[25]   Comparison of metabolic pharmacokinetics of naringin and naringenin in rabbits [J].
Hsiu, SL ;
Huang, TY ;
Hou, YC ;
Chin, DH ;
Chao, PDL .
LIFE SCIENCES, 2002, 70 (13) :1481-1489
[26]   Naringenin pre-treatment inhibits neuroapoptosis and ameliorates cognitive impairment in rats exposed to isoflurane anesthesia by regulating the PI3/Akt/PTEN signalling pathway and suppressing NF-κB-mediated inflammation [J].
Hua, Fu-Zhou ;
Ying, Jun ;
Zhang, Jing ;
Wang, Xi-Feng ;
Hu, Yan-Hui ;
Liang, Ying-Ping ;
Liu, Qin ;
Xu, Guo-Hai .
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 38 (04) :1271-1280
[27]   Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery [J].
Huang, Sheng-Teng ;
Huang, Chao-Chun ;
Sheen, Jer-Ming ;
Lin, Tsu-Kung ;
Liao, Pei-Lin ;
Huang, Wen-Liang ;
Wang, Pei-Wen ;
Liou, Chia-Wei ;
Chuang, Jiin-Haur .
AMERICAN JOURNAL OF CHINESE MEDICINE, 2016, 44 (07) :1507-1523
[28]   Long-term stability of cancer biomarkers in human serum: biomarkers of oxidative stress and redox status, homocysteine, CRP and the enzymes ALT and GGT [J].
Jansen, Eugene ;
Beekhof, Piet ;
Viezeliene, Dale ;
Muzakova, Vladimira ;
Skalicky, Jiri .
BIOMARKERS IN MEDICINE, 2015, 9 (05) :425-432
[29]   LONG-TERM FISCAL IMPLICATIONS OF MEPACT IN THE TREATMENT OF HIGH-GRADE NON-METASTATIC OSTEOSARCOMA: A BUDGET IMPACT MODEL AND A LIFETIME TAX PERSPECTIVE [J].
Johal, S. ;
Knight, C. ;
Bell, M. J. ;
Ralston, S. .
VALUE IN HEALTH, 2011, 14 (07) :A438-A438
[30]  
Kager L, 2010, THER CLIN RISK MANAG, V6, P279