Treatment adherence in renal transplant recipients: A questionnaire survey on immunosuppressants

被引：44

作者：

Ichimaru, N. ^{[1
]}

Kakuta, Y. ^{[2
,3
]}

Abe, T. ^{[1
]}

Okumi, M. ^{[1
]}

Imamura, R. ^{[1
]}

Isaka, Y. ^{[4
]}

Nonomura, N. ^{[1
]}

Kojima, Y. ^{[5
]}

Okuyama, A. ^{[1
]}

Takahara, S. ^{[4
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Specif Organ Regulat Urol, Suita, Osaka 5650871, Japan

[2] Ikeda Municipal Hosp, Dept Urol, Ikeda, Osaka, Japan

[3] Ikeda Municipal Hosp, Kidney Transplant Ctr, Ikeda, Osaka, Japan

[4] Osaka Univ, Grad Sch Med, Dept Adv Technol Transplantat, Suita, Osaka 5650871, Japan

[5] Inoue Hosp, Dept Urol, Osaka, Japan

来源：

TRANSPLANTATION PROCEEDINGS | 2008年 / 40卷 / 05期

关键词：

D O I：

10.1016/j.transproceed.2008.02.083

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction. To achieve a high graft survival rate, patient adherence to immunosuppressive therapy is critical. It is extremely difficult to establish the actual adherence status of transplant recipients; only a few surveys on the issue have been performed in Japan. Methods. We conducted a questionnaire survey mainly on treatment adherence to calcineurin inhibitors among renal transplant recipients. Results. The survey demonstrated some degree of nonadherence in a relatively high percentage of the patients. The adherence rate was significantly lower for the evening than the morning dose (McNemar test, P < .001). It significantly decreased with time following transplantation for both the morning and the evening doses (logistic regression analysis, P = .025 and <.001, respectively). Conclusions. Immunosuppressive treatment places a substantial burden on patients, some of whom cannot continue regular treatment at specified time points due to daily life restrictions after they have returned to work.

引用

页码：1362 / 1365

页数：4

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