A versatile and efficient synthesis of substituted 1H-indazoles

被引：0

作者：

Caron, S ^{[1
]}

Vazquez, E ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Proc Res & Dev, Groton, CT 06340 USA

来源：

SYNTHESIS-STUTTGART | 1999年 / 04期

关键词：

1H-indazole; phenol; mesylate; hydrazine; hydrazone;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of substituted 1H-indazole 4 from aryl mesylate 3 is described. The reaction, which proceeds through the intermediate hydrazone, was general with regard to the substituents on the arene and was applicable to several hydrazines. It was also discovered that with p-methoxyphenylhydrazine, the indazole formation was more rapid than the competitive Fischer indole synthesis.

引用

页码：588 / 592

页数：5

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