A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children

被引：49

作者：

de Melo, Fabricio Freire ^{[1
,2
]}

Camargos Rocha, Andreia Maria ^{[1
]}

Rocha, Gifone Aguiar ^{[1
]}

Sousa Pietra Pedroso, Silvia Helena ^{[1
]}

Batista, Sergio de Assis ^{[1
,2
]}

Fonseca de Castro, Lucia Porto ^{[3
]}

Carvalho, Simone Diniz ^{[4
]}

Souto Bittencourt, Paulo Fernando ^{[4
]}

de Oliveira, Celso Afonso ^{[1
]}

Correa-Oliveira, Rodrigo ^{[5
]}

Magalhaes Queiroz, Dulciene Maria ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Med, Lab Res Bacteriol, BR-30130100 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, BR-30130100 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Med, Dept Pathol, BR-30130100 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Univ Hosp, Endoscopy Serv, BR-30130100 Belo Horizonte, MG, Brazil

[5] Fundacao Oswaldo Cruz FIOCRUZ MINAS, Ctr Pesquisa Rene Rachou, Lab Imunol Celular & Mol, Belo Horizonte, MG, Brazil

来源：

MICROBES AND INFECTION | 2012年 / 14卷 / 04期

关键词：

Helicobacter pylori; Th17; T-reg; Children; Adults; TGF-BETA; HELPER-CELLS; INFECTION; MUCOSA; DIFFERENTIATION; CYTOKINES; INTERLEUKIN-12; FOXP3; TH1;

D O I：

10.1016/j.micinf.2011.11.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T-reg cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T-reg-associated cytokines of children and adults. IL-6, IL-10 and TGF-beta 1 levels and Foxp3(+) cell numbers were higher, but IL-1 beta, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T-reg instead of Th17 cell response to H. pylori-infection predominates in children. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：341 / 347

页数：7

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