A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children

被引：49
|
作者：
de Melo, Fabricio Freire [1 ,2 ]
Camargos Rocha, Andreia Maria [1 ]
Rocha, Gifone Aguiar [1 ]
Sousa Pietra Pedroso, Silvia Helena [1 ]
Batista, Sergio de Assis [1 ,2 ]
Fonseca de Castro, Lucia Porto [3 ]
Carvalho, Simone Diniz [4 ]
Souto Bittencourt, Paulo Fernando [4 ]
de Oliveira, Celso Afonso [1 ]
Correa-Oliveira, Rodrigo [5 ]
Magalhaes Queiroz, Dulciene Maria [1 ]
机构：
[1] Univ Fed Minas Gerais, Fac Med, Lab Res Bacteriol, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, BR-30130100 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Fac Med, Dept Pathol, BR-30130100 Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Univ Hosp, Endoscopy Serv, BR-30130100 Belo Horizonte, MG, Brazil
[5] Fundacao Oswaldo Cruz FIOCRUZ MINAS, Ctr Pesquisa Rene Rachou, Lab Imunol Celular & Mol, Belo Horizonte, MG, Brazil
来源：
MICROBES AND INFECTION | 2012年 / 14卷 / 04期
关键词：
Helicobacter pylori; Th17; T-reg; Children; Adults; TGF-BETA; HELPER-CELLS; INFECTION; MUCOSA; DIFFERENTIATION; CYTOKINES; INTERLEUKIN-12; FOXP3; TH1;
D O I：
10.1016/j.micinf.2011.11.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T-reg cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T-reg-associated cytokines of children and adults. IL-6, IL-10 and TGF-beta 1 levels and Foxp3(+) cell numbers were higher, but IL-1 beta, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T-reg instead of Th17 cell response to H. pylori-infection predominates in children. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：341 / 347
页数：7
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