A regulatory instead of an IL-17 T response predominates in Helicobacter pylori-associated gastritis in children

被引：49
|
作者：
de Melo, Fabricio Freire [1 ,2 ]
Camargos Rocha, Andreia Maria [1 ]
Rocha, Gifone Aguiar [1 ]
Sousa Pietra Pedroso, Silvia Helena [1 ]
Batista, Sergio de Assis [1 ,2 ]
Fonseca de Castro, Lucia Porto [3 ]
Carvalho, Simone Diniz [4 ]
Souto Bittencourt, Paulo Fernando [4 ]
de Oliveira, Celso Afonso [1 ]
Correa-Oliveira, Rodrigo [5 ]
Magalhaes Queiroz, Dulciene Maria [1 ]
机构：
[1] Univ Fed Minas Gerais, Fac Med, Lab Res Bacteriol, BR-30130100 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, BR-30130100 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Fac Med, Dept Pathol, BR-30130100 Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Univ Hosp, Endoscopy Serv, BR-30130100 Belo Horizonte, MG, Brazil
[5] Fundacao Oswaldo Cruz FIOCRUZ MINAS, Ctr Pesquisa Rene Rachou, Lab Imunol Celular & Mol, Belo Horizonte, MG, Brazil
来源：
MICROBES AND INFECTION | 2012年 / 14卷 / 04期
关键词：
Helicobacter pylori; Th17; T-reg; Children; Adults; TGF-BETA; HELPER-CELLS; INFECTION; MUCOSA; DIFFERENTIATION; CYTOKINES; INTERLEUKIN-12; FOXP3; TH1;
D O I：
10.1016/j.micinf.2011.11.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Th17 cells seem to have an important role in the efficacy of vaccines against Helicobacter pylori. Because children are a target group for human vaccination and Th17/T-reg cells have intrinsically linked and antagonic commitments, we compared the gastric levels of Th17- and T-reg-associated cytokines of children and adults. IL-6, IL-10 and TGF-beta 1 levels and Foxp3(+) cell numbers were higher, but IL-1 beta, IL-17A and IL-23 were lower in infected children than in infected adults. In conclusion T-reg instead of Th17 cell response to H. pylori-infection predominates in children. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：341 / 347
页数：7
相关论文
共 50 条
  • [1] Endoscopic features of lymphoid follicles in Helicobacter pylori-associated chronic gastritis
    Hayashi, Seishu
    Imamura, Jun
    Kimura, Kiminori
    Saeki, Shunichi
    Hishima, Tsunekazu
    DIGESTIVE ENDOSCOPY, 2015, 27 (01) : 53 - 60
  • [2] Increased mucosal inflammatory cytokines in children with Helicobacter pylori-associated gastritis
    Kutukculer, N
    Aydogdu, S
    Goksen, D
    Caglayan, S
    Yagcyi, RV
    ACTA PAEDIATRICA, 1997, 86 (09) : 928 - 931
  • [3] Proinflammatory cytokine expression in gastric tissue from children with Helicobacter pylori-associated gastritis
    Guiraldes, E
    Duarte, I
    Peña, A
    Godoy, A
    Espinosa, MN
    Bravo, R
    Larraín, F
    Schultz, M
    Harris, P
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2001, 33 (02) : 127 - 132
  • [4] Expression of cytokeratins 7 and 20 in Helicobacter pylori-associated chronic gastritis in children
    Cohen, M
    Rúa, EC
    Balcarce, N
    Drut, R
    PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2004, 7 (02) : 180 - 186
  • [5] Nature and extent of gastric lesions in symptomatic Chilean children with Helicobacter pylori-associated gastritis
    Guiraldes, E
    Peña, A
    Duarte, I
    Triviño, X
    Schultz, M
    Larraín, F
    Espinosa, MN
    Harris, P
    ACTA PAEDIATRICA, 2002, 91 (01) : 39 - 44
  • [6] Indicators of activity of Helicobacter pylori-associated antral gastritis in children with GERD in age groups
    Polivanova, Tamara
    Vshivkov, Vitaliy
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2023, 38 : 70 - 70
  • [7] Gastric neuroendocrine tumor with Helicobacter pylori-associated chronic gastritis
    Serio, Giovanni
    Dell'Anna, Armando
    Debenedittis, Anna
    Stasi, Elisa
    Cascarano, Maria Arcangela
    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2020, 75 : 361 - 366
  • [8] Analysis of Gene Expression in Helicobacter pylori-associated Nodular Gastritis in Children Using Microarray
    Yang, Hye Ran
    Ko, Jae Sung
    Seo, Jeong Kee
    PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION, 2010, 13 (01) : 7 - 22
  • [9] Indicators of activity of Helicobacter pylori-associated antral gastritis in children with GERD in age groups
    Polivanova, Tamara
    Vshivkov, Vitaliy
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2023, 38 : 70 - 70
  • [10] Distribution of gastric lymphoid follicles in helicobacter pylori-associated gastritis
    Sokmen, Mehmet
    Sakiz, Damlanur
    Akbayir, Nihat
    Karaca, Cetin
    Ersoy, Ozdal
    Alkim, Canan
    Demirsoy, Huseyin
    HEPATO-GASTROENTEROLOGY, 2007, 54 (73) : 285 - 289
12345