Aqueous-Phased Electrospun Bioactive Glass Mineralized Gelatin-Pectin Hybrid Composite Fiber Matrix For 7-Dehydrocholesterol Delivery

Ultrafine fibers and a bioactive glass mineralized fibrous mat of gelatin-pectin blends were produced by electrospinning in an aqueous phase. Herein, the gelatin-pectin blend was used as a template for the in situ mineralization of bioactive glass particles during the electrospinning of gelatin-pectin based hybrid composite fiber matrix. Further, in situ mineralized bioactive glass along with the fibrous mat functioned as a site for 7-dehydrocholesterol, i. e., vitamin-D precursor. This engineered fibrous mat resulted in the sustained release of the drug, which is necessary for the strengthening of the neo regenerated bones. The fibrous mat also exhibited excellent bioactivity in simulated body fluid. Additionally, the hybrid composite fiber mat was observed to possess remarkable cytocompatibility with osteoblast cells and showed cell proliferation on the surface of the fibrous mat.