LncRNAs Transcriptome Analysis Revealed Potential Mechanisms of Selenium to Mastitis in Dairy Cows

被引：4

作者：

Jing, Hongyuan ^{[1
]}

Chen, Yu ^{[1
]}

Qiu, Changwei ^{[1
]}

Guo, Meng-yao ^{[1
]}

机构：

[1] Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2022年 / 200卷 / 10期

关键词：

Selenium; Mastitis; Cow; LncRNAs; ATTENUATES INFLAMMATORY RESPONSES;

D O I：

10.1007/s12011-021-03042-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The trace element selenium (Se) plays an indispensable role in the growth of humans and animals due to its antioxidant function. Mastitis is one of the most important diseases affecting the dairy industry in the world. In recent years, long non-coding RNAs (lncRNAs) have been implicated in a series of cellular processes and disease development processes. RNA-sequencing technology was used to characterize lncRNA profiles and compared transcriptomic dynamics among the control group, the LPS group, and the Se-treated group to highlight the potential roles and functions of lncRNAs in the mammary epithelial cells of dairy cows. We identified 14 specific lncRNAs related to Se and their predicted target genes. KEGG and GO functional annotation was used to elucidate their biological function and the pathways in which they may be involved. The present study provides novel insights for exploring the molecular markers for the protection of Se against mastitis in dairy cows.

引用

页码：4316 / 4324

页数：9

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