The developmental biology of Dishevelled: an enilgmatic protein governing cell fate and cell polarity

被引:378
作者
Wallingford, JB [1 ]
Habas, R
机构
[1] Univ Texas, Sect Mol Cell & Dev Biol, Austin, TX 78712 USA
[2] Univ Texas, Inst Mol & Cellular Biol, Austin, TX 78712 USA
[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Piscataway, NJ 08854 USA
[4] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Piscataway, NJ 08854 USA
来源
DEVELOPMENT | 2005年 / 132卷 / 20期
关键词
D O I
10.1242/dev.02068
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Dishevelled protein regulates many developmental processes in animals ranging from Hydra to humans. Here, we discuss the various known signaling activities of this enigmatic protein and focus on the biological processes that Dishevelled controls. Through its many signaling activities, Dishevelled plays important roles in the embryo and the adult, ranging from cell-fate specification and cell polarity to social behavior. Dishevelled also has important roles in the governance of polarized cell divisions, in the directed migration of individual cells, and in cardiac development and neuronal structure and function.
引用
收藏
页码:4421 / 4436
页数:16
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