No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma

被引：5
作者：
Havranek, Ondrej [2 ,3 ]
Spacek, Martin [4 ]
Hubacek, Petr [5 ]
Mocikova, Heidi [4 ]
Benesova, Katerina [2 ,3 ]
Soucek, Pavel [6 ]
Trneny, Marek [2 ,3 ]
Kleibl, Zdenek [1 ]
机构：
[1] Charles Univ Prague, Fac Med 1, Inst Biochem & Expt Oncol, Prague 12853 2, Czech Republic
[2] Charles Univ Prague, Fac Med 1, Dept Hematol, Dept Med 1, Prague 12853 2, Czech Republic
[3] Gen Univ Hosp, Prague, Czech Republic
[4] Charles Univ Prague, Fac Med 3, Univ Hosp Kralovske Vinohrady, Dept Clin Hematol, Prague 12853 2, Czech Republic
[5] Charles Univ Prague, Fac Med 2, Motol Univ Hosp, Dept Pediat Hematol & Oncol,Dept Med Microbiol, Prague 12853 2, Czech Republic
[6] Natl Inst Publ Hlth, Toxicogen Unit, Prague, Czech Republic
来源：
LEUKEMIA RESEARCH | 2011年 / 35卷 / 08期
关键词：
TP53 gene (p53); Arg72Pro polymorphism (R72P); Non-Hodgkin lymphoma; Hodgkin lymphoma; Genetic predisposition; Prognosis; B-CELL LYMPHOMA; FOLLICULAR LYMPHOMA; GERMLINE VARIATION; DNA-REPAIR; GENES; P53; MUTATIONS; SURVIVAL; ARG72PRO; CANCER;
D O I：
10.1016/j.leukres.2011.04.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of the TP53 gene's R72P polymorphism in non-Hodgkin lymphoma (NHL) has been analyzed in several studies but it has not been studied in Hodgkin lymphoma (HL). We have evaluated the role of R72P in 340 NHL and 298 HL patients. There was no difference in the R72P frequency between analyzed lymphoma cases and 749 controls. We found no association of R72P with the risk of NHL and HL development [OR(ArgPro/ProPro) = 0.9 (95% CI 0.7-1.2) and 1.2 (95% CI 0.9-1.5), respectively] or with survival. Our results support the evidence that R72P is not a prognostic factor in Caucasian NHL patients, and they indicate its irrelevance for HL development or prognosis. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1117 / 1119
页数：3
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