A new high resolution radioimager for the quantitative analysis of radiolabelled molecules in tissue section

We present a high-speed, high-resolution imager of beta particles. It is devoted to be used in autoradiography experiments such as receptor binding or in situ hybridization experiments, either instead of, or in complement with autoradiographic film and emulsions. It allows the user to locate and perform quantitative analyses of (H-3, C-14, S-35, P-33, P-32, I-125) labelled molecules with a 15 mu m spatial resolution on a 0.9 x 1.3 cm(2) sensitive area. Combining recent techniques (specific scintillator thin sheets and intensified charge-coupled device (CCD)) this imager offers a wide dynamic range and real-time acquisition. (C) 1998 Elsevier Science B.V. All rights reserved.