MarkUs: a server to navigate sequence-structure-function space

被引：12

作者：

Fischer, Markus ^{[1
]}

Zhang, Qiangfeng Cliff ^{[1
]}

Dey, Fabian ^{[1
]}

Chen, Brian Y. ^{[1
]}

Honig, Barry ^{[1
]}

Petrey, Donald ^{[1
]}

机构：

[1] Columbia Univ, Ctr Computat Biol & Bioinformat, Dept Biochem & Mol Biophys, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

NUCLEIC ACIDS RESEARCH | 2011年 / 39卷

基金：

美国国家卫生研究院;

关键词：

PROTEIN; ALIGNMENT; DATABASE; VISUALIZATION; SURFACE;

D O I：

10.1093/nar/gkr468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe MarkUs, a web server for analysis and comparison of the structural and functional properties of proteins. In contrast to a 'structure in/function out' approach to protein function annotation, the server is designed to be highly interactive and to allow flexibility in the examination of possible functions, suggested either automatically by various similarity measures or specified by a user directly. This is combined with tools that allow a user to assess independently whether or not a suggested function is consistent with the bioinformatic and biophysical properties of a given query structure, further allowing the user to generate testable hypotheses. The server is available at http://wiki.c2b2.columbia.edu/honiglab_public/index.php/Software:Mark-Us.

引用

页码：W357 / W361

页数：5

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