Izumiphenazine D, a New Phenazoquinoline N-Oxide from Streptomyces sp IFM 11204

被引：23

作者：

Abdelfattah, Mohamed S. ^{[1
,2
]}

Toume, Kazufumi ^{[1
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[2] Helwan Univ, Fac Sci, Dept Chem, Cairo 11795, Egypt

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 04期

基金：

日本学术振兴会;

关键词：

Streptomyces sp; phenazine; spectroscopy; N-oxide; CONTAINING NATURAL-PRODUCTS; KITASATOSPORA SP IFM10917; TUMOR-CELLS; RESISTANCE; INHIBITORS; FUZANINS;

D O I：

10.1248/cpb.59.508

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new phenazine derivative named izumiphenazine D (I), together with three known metabolites, 1-hydroxyphenazine (2), phenazine-1-carboxylic acid (3) and 6-hydroxyphenazine-1-carboxylic acid (4) has been isolated from the ethyl acetate extract of culture of Streptomyces sp. IFM 11204. The structure of I was established via spectroscopic methods, including 1D- and 2D-NMR measurements.

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收藏

页码：508 / 510

页数：3

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