Prenatal Drug Exposure and Adolescent Cortisol Reactivity: Association with Behavioral Concerns

被引:11
作者
Buckingham-Howes, Stacy [1 ,2 ]
Mazza, Dayna [1 ]
Wang, Yan [1 ]
Granger, Douglas A. [2 ,3 ,4 ,5 ,6 ,7 ]
Black, Maureen M. [1 ]
机构
[1] Univ Maryland, Sch Med, Dept Pediat, 737 W Lombard St,Suite 161, Baltimore, MD 21201 USA
[2] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA
[3] Johns Hopkins Univ, Dept Acute & Chron Care, Sch Nursing, Baltimore, MD USA
[4] Johns Hopkins Univ, Dept Populat Family & Reprod Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA
[5] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA
[6] Univ Nebraska, Salivary Biosci Lab, Lincoln, NE USA
[7] Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
关键词
cortisol reactivity; prenatal drug exposure; drug use; externalizing problems; STRESS REACTIVITY; COCAINE EXPOSURE; ADVERSITY; CHILDREN; RISK;
D O I
10.1097/DBP.0000000000000338
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objective: To examine stress reactivity in a sample of adolescents with prenatal drug exposure (PDE) by examining the consequences of PDE on stress-related adrenocortical reactivity, behavioral problems, and drug experimentation during adolescence. Methods: Participants (76 PDE, 61 non-drug exposed [NE]; 99% African-American; 50% male; mean age = 14.17 yr, SD = 1.17) provided a urine sample, completed a drug use questionnaire, and provided saliva samples (later assayed for cortisol) before and after a mild laboratory stress task. Caregivers completed the Behavior Assessment System for Children, Second Edition (BASC II) and reported their relationship to the adolescent. Results: The NE group was more likely to exhibit task-related cortisol reactivity compared to the PDE group. Overall behavior problems and drug experimentation were comparable across groups with no differences between PDE and NE groups. In unadjusted mediation analyses, cortisol reactivity mediated the association between PDE and BASC II aggression scores (95% bootstrap confidence interval [CI], 0.04-4.28), externalizing problems scores (95% bootstrap CI, 0.03-4.50), and drug experimentation (95% bootstrap CI, 0.001-0.54). The associations remain with the inclusion of gender as a covariate but not when age is included. Conclusion: Findings support and expand current research in cortisol reactivity and PDE by demonstrating that cortisol reactivity attenuates the association between PDE and behavioral problems (aggression) and drug experimentation. If replicated, PDE may have long-lasting effects on stress-sensitive physiological mechanisms associated with behavioral problems (aggression) and drug experimentation in adolescence.
引用
收藏
页码:565 / 572
页数:8
相关论文
共 29 条
[1]  
[Anonymous], 2013, NSDUH Series H-46, P13
[3]   Prenatal Drug Exposure Moderates the Association between Stress Reactivity and Cognitive Function in Adolescence [J].
Buckingham-Howes, Stacy ;
Bento, Samantha P. ;
Scaletti, Laura A. ;
Koenig, James I. ;
Granger, Douglas A. ;
Black, Maureen M. .
DEVELOPMENTAL NEUROSCIENCE, 2014, 36 (3-4) :329-337
[4]   Systematic Review of Prenatal Cocaine Exposure and Adolescent Development [J].
Buckingham-Howes, Stacy ;
Berger, Sarah Shafer ;
Scaletti, Laura A. ;
Black, Maureen M. .
PEDIATRICS, 2013, 131 (06) :E1917-E1936
[5]   Prenatal cocaine exposure, gender, and adolescent stress response: A prospective longitudinal study [J].
Chaplin, Tara M. ;
Freiburger, Matthew B. ;
Mayes, Linda C. ;
Sinha, Rajita .
NEUROTOXICOLOGY AND TERATOLOGY, 2010, 32 (06) :595-604
[6]   Interaction of Adrenocortical Activity and Autonomic Arousal on Children's Externalizing and Internalizing Behavior Problems [J].
Chen, Frances R. ;
Raine, Adrian ;
Soyfer, Liana ;
Granger, Douglas A. .
JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 2015, 43 (01) :189-202
[7]   Cortisol Reactivity to Social Stress as a Mediator of Early Adversity on Risk and Adaptive Outcomes [J].
Conradt, Elisabeth ;
Abar, Beau ;
Lester, Barry M. ;
LaGasse, Linda L. ;
Shankaran, Seetha ;
Bada, Henrietta ;
Bauer, Charles R. ;
Whitaker, Toni M. ;
Hammond, Jane A. .
CHILD DEVELOPMENT, 2014, 85 (06) :2279-2298
[8]   Focus on Methodology: Salivary bioscience and research on adolescence: An integrated perspective [J].
Granger, Douglas A. ;
Fortunato, Christine K. ;
Beltzer, Emilie K. ;
Virag, Marta ;
Bright, Melissa A. ;
Out, Dorothee .
JOURNAL OF ADOLESCENCE, 2012, 35 (04) :1081-1095
[9]   Mental Health Outcomes in Emerging Adults Exposed to Childhood Maltreatment: The Moderating Role of Stress Reactivity [J].
Hagan, Melissa J. ;
Roubinov, Danielle S. ;
Mistler, Amy Kraft ;
Luecken, Linda J. .
CHILD MALTREATMENT, 2014, 19 (3-4) :156-167
[10]  
Johnston LD., 2011, Monitoring The Future National Results On Drug Use, 1975-2010