Cytocompatibility property evaluation of gas pressure sintered SiAlON-SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells

被引：18

作者：

Kumar, Alok ^{[2
]}

Mallik, Awadesh Kumar ^{[3
]}

Acikbas, Nurcan Calis ^{[4
]}

Yaygingol, Merve ^{[5
]}

Kara, Ferhat ^{[5
]}

Mandal, Hasan ^{[4
,6
]}

Basu, Debabrata ^{[3
]}

Biswas, Krishanu ^{[2
]}

Basu, Bikramjit ^{[1
]}

机构：

[1] Indian Inst Sci, Ctr Mat Res, Bangalore 560012, Karnataka, India

[2] Indian Inst Technol, Dept Mat Sci & Engn, Kanpur 208016, Uttar Pradesh, India

[3] CSIR, Cent Glass & Ceram Res Inst, Kolkata 700032, India

[4] MDA Adv Ceram Ltd Co, Eskisehir, Turkey

[5] Anadolu Univ, Dept Mat Sci & Engn, Eskisehir, Turkey

[6] Sabanci Univ, Mat Sci & Engn Programme, Istanbul, Turkey

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2012年 / 32卷 / 03期

关键词：

SiAlON; SiC; Composite; In vitro; Cytocompatibility; STRUCTURAL ORTHOPEDIC IMPLANTS; IMPROVED FRACTURE-TOUGHNESS; SILICON-NITRIDE; CYTOTOXICITY EVALUATION; MICROSTRUCTURAL DESIGN; PHASE-TRANSFORMATIONS; MECHANICAL-PROPERTIES; METAL RELEASE; CARBIDE; ALUMINA;

D O I：

10.1016/j.msec.2011.11.019

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Although the oxide ceramics have widely been investigated for their biocompatibility, non-oxide ceramics, such as SiAlON and SiC are yet to be explored in detail. Lack of understanding of the biocompatibility restricts the use of these ceramics in clinical trials. It is hence, essential to carry out proper and thorough study to assess cell adhesion, cytocompatibility and cell viability on the non-oxide ceramics for the potential applications. In this perspective, the present research work reports the cytocompatibility of gas pressure sintered SiAlON monolith and SiAlON-SiC composites with varying amount of SIC, using connective tissue cells (L929) and bone cells (Saos-2). The quantification of cell viability using MTT assay reveals the non-cytotoxic response. The cell viability has been found to be cell type dependent. An attempt has been made to discuss the cytocompatibility of the developed composites in the light of SiC content and type of sinter additives. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：464 / 469

页数：6

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