Practical considerations for cangrelor use in patients with acute coronary syndromes

被引：14

作者：

Leonardi, Sergio ^{[1
]}

Bhatt, Deepak L. ^{[2
]}

机构：

[1] Fdn IRCCS Policlin S Matteo, Ple Golgi 2, I-27100 Pavia, Italy

[2] Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA

来源：

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE | 2019年 / 8卷 / 01期

关键词：

Acute coronary syndromes; cangrelor; percutaneous coronary intervention; ACHIEVE OPTIMAL MANAGEMENT; GLYCOPROTEIN IIB/IIIA INHIBITORS; PLATELET INHIBITION; CHAMPION PHOENIX; MYOCARDIAL-INFARCTION; STANDARD THERAPY; UNIVERSAL DEFINITION; COMPARING CANGRELOR; POOLED ANALYSIS; TICAGRELOR;

D O I：

10.1177/2048872617707960

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cangrelor, the first and currently only available intravenous P2Y(12) receptor antagonist, has been approved and is now being used in patients with coronary artery disease requiring percutaneous coronary intervention. The rationale for cangrelor use is most robust in patients requiring an immediate, profound, and predictable level of P2Y(12) inhibition - especially in patients with acute coronary syndromes. Herein we summarize the drug development program and reflect on practical considerations for clinicians on cangrelor use in the acute setting surrounding percutaneous coronary intervention, including selection of patients, concomitant administration of glycoprotein IIb/IIIa inhibitors and transition strategies from intravenous to oral P2Y(12) receptor antagonists.

引用

页码：39 / 44

页数：6

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