Detection and typing of human papillomavirus in non-small cell lung cancer

被引:28
作者
Zafer, E
Ergun, MA
Alver, G
Sahin, FI
Yavuzer, S
Ekmekci, A [1 ]
机构
[1] Gazi Univ, Fac Med, Dept Med Biol & Genet, TR-06500 Ankara, Turkey
[2] Ankara Univ, Fac Med, Dept Thorac Surg, TR-06100 Ankara, Turkey
关键词
human papillomavirus; non-small cell lung cancer; polymerase chain reaction; restriction fragment length polymorphism;
D O I
10.1159/000075655
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: Lung cancer is the most frequent cause of death in both men and women. Smoking is the greatest risk factor for lung cancer and the relation of human papillomavirus (HPV) infection with lung cancer has been reported. HPV can be detected in small cell lung cancer samples with the methods like in situ hybridization, polymerase chain reaction (PCR), Southern blotting, dot blotting. Objective: We aimed to detect and type HPV infection in non-small cell lung carcinoma tissue samples. Methods: Tumor samples from 40 patients were collected during surgery and PCR and restriction fragment length polymorphism (RFLP) were used in order to detect HPV infection in the samples. Results: Two HPV DNA were detected among 40 of the patients, revealing a low frequency of HPV in the samples. Conclusions: HPV can be regarded as an environmental factor in tumor development. There might be a relationship between HPV infection and some non-small cell lung cancers, especially in the smoking group. Copyright (C) 2004 S. Karger AG, Basel.
引用
收藏
页码:88 / 90
页数:3
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