Memory-enhancing effects of benzodiazepines in mice

被引：7
|
作者：
Voigt, JP [1 ]
Morgenstern, E [1 ]
Fink, H [1 ]
机构：
[1] BIOPHARM GMBH,D-10315 BERLIN,GERMANY
来源：
EUROPEAN NEUROPSYCHOPHARMACOLOGY | 1996年 / 6卷 / 03期
关键词：
inhibitory avoidance; memory; mouse; clonazepam; diazepam;
D O I：
10.1016/0924-977X(96)00019-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In the present study, post-trial effects of clonazepam and diazepam on inhibitory avoidance learning under two different experimental conditions (i.e., 0.25 or 0.75 mA footshock) have been investigated. Both clonazepam (0.5 mg/kg) and diazepam (2 and 8 mg/kg) enhanced retention when administered immediately after the 0.25 mA footshock applied during training of the inhibitory avoidance task. In contrast, clonazepam and diazepam proved ineffective after the 0.75 mA footshock. The results suggest a post-training memory enhancing effect of clonazepam and diazepam depending on the experimental conditions.
引用
收藏
页码：253 / 255
页数：3
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