The Role of FOXP3 in Human Cancers

被引：0

作者：

Szylberg, Lukasz ^{[1
]}

Karbownik, Dominika ^{[1
]}

Marszalek, Andrzej ^{[1
,2
,3
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Clin Pathomorphol, Torun, Poland

[2] Poznan Univ Med Sci, Dept Oncol Pathol, Poznan, Poland

[3] Greater Poland Canc Ctr, Poznan, Poland

来源：

ANTICANCER RESEARCH | 2016年 / 36卷 / 08期

关键词：

FOXP3; cancer; tumor immunity; review; REGULATORY T-CELLS; GASTRIC-CANCER; EXPRESSION; MELANOMA; POPULATION; INHIBITION; DEFINES; TUMORS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FOXP3 transcription factor can be observed as the main component of the immune system expressed in regulatory T (Treg) cells that regulate hemostasis and self-tolerance. Moreover, the altered expression of FOXP3 was found in autoimmune diseases, benign tumors and carcinomas. Latest reports indicate that the FOXP3 gene mutation can contribute to carcinogenesis, which can be associated with immune response abnormalities. Infiltration of the Treg cells into tumor cells can be associated with prognosis. Understanding the biology of the FOXP3 gene may be crucial in developing new immunotherapeutics.

引用

页码：3789 / 3794

页数：6

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