β-TCP bone substitutes in tibial plateau depression fractures

Background: The use of beta-tricalciumphospate (beta-TCP, Cerasorb (R)) ceramics as an alternative for autologous bone-grafting has been outlined previously, however with no study focusing on both clinical and histological outcomes of beta-TCP application in patients with multi-fragment tibial plateau fractures. The aim of this study was to analyze the long-term results of beta-TCP in patients with tibial plateau fractures. Methods: 52 patients were included in this study. All patients underwent open surgery with beta-TCP block or granulate application. After a mean follow-up of 36 months (14-64 months), the patients were reviewed. Radiography and computed-tomography were performed, while the Rasmussen score was obtained for clinical outcome. Furthermore, seven patients underwent biopsy during hardware removal, which was subsequently analyzed by histology and backscattered electron microscopy.(BSEM). Results: An excellent reduction with two millimeters or less of residual incongruity was achieved in 83% of the patients. At follow-up, no further changes occurred and no nonunions were observed. Functional outcome was good to"excellent in 82%. Four patients underwent revision surgery due to reasons unrelated to the bone substitute material. Histologic analyses indicated that new bone was built around the beta-TCP-grafts, however a complete resorption of beta-TCP was not observed. Discussion: beta-TCP combined with internal fixation represents an effective and safe treatment of tibial plateau depression fractures with good functional recovery. While its osteoconductivity seems to be successful, the biological degradation and replacement of beta-TCP is less pronounced in humans than previous animal studies have indicated. (C) 2017 Elsevier B.V. All rights reserved.