Role of tumor microenvironment in the pathobiology of ovarian cancer: Insights and therapeutic opportunities

被引：48
作者：
Ghoneum, Alia [1 ]
Afify, Hesham [1 ]
Salih, Ziyan [2 ]
Kelly, Michael [3 ]
Said, Neveen [1 ,2 ,4 ]
机构：
[1] Wake Forest Univ, Sch Med, Dept Canc Biol, Med Ctr Blvd, Winston Salem, NC 27157 USA
[2] Wake Forest Univ, Sch Med, Dept Pathol, Med Ctr Blvd, Winston Salem, NC 27157 USA
[3] Wake Forest Univ, Sch Med, Dept Obstet & Gynecol, Winston Salem, NC 27157 USA
[4] Wake Forest Univ, Sch Med, Dept Urol, Med Ctr Blvd, Winston Salem, NC 27157 USA
来源：
CANCER MEDICINE | 2018年 / 7卷 / 10期
关键词：
TO-MESENCHYMAL TRANSITION; CARCINOMA-ASSOCIATED-FIBROBLASTS; LYSOPHOSPHATIDIC ACID; MESOTHELIAL CELLS; PERITONEAL METASTASIS; EXTRACELLULAR-MATRIX; PROGNOSTIC-FACTORS; EPITHELIAL CANCER; CTLA-4; BLOCKADE; I COLLAGEN;
D O I：
10.1002/cam4.1741
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer is the fifth most common cancer affecting women and at present, stands as the most lethal gynecologic malignancy. The poor disease outcome is due to the nonspecific symptoms and the lack of effective treatment at advanced stages. Thus, it is of utmost importance to understand ovarian carcinoma through several lenses and to dissect the role that the unique peritoneal tumor microenvironment plays in ovarian cancer progression and metastasis. This review seeks to highlight several determinants of this unique tumor microenvironment, their influence on disease outcome and ongoing clinical trials targeting these determinants.
引用
收藏
页码：5047 / 5056
页数：10
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