BIOMIMETIC MATRICES FOR HISTOLOGICAL PROCESSING

In human or veterinary histological diagnosis there is an urgent need to reduce consumable costs by merging biopsies from the same patients to facilitate high-accuracy diagnoses. Our paper aims to examine and demonstrate that BxFrame is a medical device TM that can be used as a support matrix for the incorporation of several biopsies. The "ideal" material must be suited for all preparative techniques employed in routine clinical diagnosis, starting from fresh or fixed biopsies, eliminating the possibility of fragmentation, maintaining orientation, and reducing the need of tissue manipulation. The experiments were based on rheological testing of several materials of different compositions following decalcification with routinely employed methods, as well as by assessing the quality of the resultant histological preparations by means of different dehydration processes (routinely used nowadays in histology laboratories) with different working times. The results obtained after testing were marked with the scores "Very good", "Good", "Sufficient" and "Insufficient".