Nanoparticle-Mediated Delivery of Bleomycin

被引：41
作者：
Georgelin, Thomas [1 ]
Bombard, Sophie [2 ]
Siaugue, Jean-Michel [1 ]
Cabuil, Valerie [1 ]
机构：
[1] Univ Paris 06, PECSA, UPMC CNRS ESPCI ENSCP, UMR 7195, F-75252 Paris 05, France
[2] Univ Paris 05, INSERM, UMR S 1007, UMR 8601, F-75006 Paris 06, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 47期
关键词：
bleomycin; cytoxicity; drug delivery; nanoparticles; theranostics; IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; IN-VIVO; MAGNETIC NANOPARTICLES; SILICA NANOPARTICLES; CANCER THERAPEUTICS; SOLID TUMORS; PARTICLES; THERAPY; HYPERTHERMIA;
D O I：
10.1002/anie.201003316
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Direct delivery: Multifunctionalized magnetic nanoparticles, which are highly stable and positively charged, induce strong interactions with cells and nuclei, thus confining bleomycin (BLM) close to its DNA target (see picture; PEG=polyethylene glycol). Grafted BLM can induce significant damage in DNA and cancerous cells. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8897 / 8901
页数：5
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