Ibrutinib plus CIT for R/R mature B-NHL in children (SPARKLE trial): initial safety, pharmacokinetics, and efficacy

被引：10

作者：

Burke, G. A. Amos ^{[1
]}

Beishuizen, Auke ^{[2
]}

Bhojwani, Deepa ^{[3
]}

Burkhardt, Birgit ^{[4
]}

Minard-Colin, Veronique ^{[5
]}

Norris, Robin E. ^{[6
]}

Kabickova, Edita ^{[7
,8
]}

Pinarli, F. Guclu ^{[9
]}

Tacyildiz, Nurdan ^{[10
]}

Howes, Angela ^{[11
]}

de Jong, Jan ^{[12
]}

Liu, Grace ^{[13
]}

Nottage, Kerri ^{[13
]}

Salman, Mariya ^{[13
]}

de Trixhe, Xavier Woot ^{[14
]}

Cairo, Mitchell ^{[15
]}

机构：

[1] Addenbrookes Hosp, Cambridge Univ Hosp NHS Fdn Trust, Dept Paediat Haematol Oncol & Palliat Care, Cambridge, England

[2] Princess Maxima Ctr Pediat Oncol, Dept Hematol & Oncol, Utrecht, Netherlands

[3] Univ Southern Calif, Keck Sch Med, Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Los Angeles, CA 90007 USA

[4] Univ Hosp Munster, Pediat Hematol & Oncol, Munster, Germany

[5] Gustave Roussy, Dept Child & Adolescent Canc, Paris, France

[6] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA

[7] Charles Univ Prague, Dept Pediat Hematol & Oncol, Prague, Czech Republic

[8] Univ Hosp Motol, Prague, Czech Republic

[9] Gazi Univ, Dept Pediat Oncol, Ankara, Turkey

[10] Ankara Univ, Dept Pediat Hematol & Oncol, Ankara, Turkey

[11] Janssen R&D LLC, Clin Oncol, High Wycombe, Bucks, England

[12] Janssen R&D LLC, Clin Pharmacol, San Diego, CA USA

[13] Janssen R&D LLC, Clin Oncol, Raritan, NJ USA

[14] Janssen R&D LLC, Pharmacometr, Beerse, Belgium

[15] New York Med Coll, Dept Pediat Med Pathol Microbiol & Immunol & Cell, Valhalla, NY 10595 USA

来源：

LEUKEMIA | 2020年 / 34卷 / 08期

关键词：

KINASE INHIBITOR IBRUTINIB; CELL;

D O I：

10.1038/s41375-020-0749-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：2271 / 2275

页数：5

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