What changes can we expect in the brain of glaucoma patients?

被引：61

作者：

Gupta, Neeru ^{[1
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Yuecel, Yeni H. ^{[1
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机构：

[1] Univ Toronto, Dept Ophthalmol, Toronto, ON M5S 1A1, Canada

[2] Univ Toronto, Dept Vis Sci, Toronto, ON, Canada

[3] Univ Toronto, Lab Med Pathol, Toronto, ON, Canada

[4] Univ Toronto, Ophtal Pathol Lab, Toronto, ON, Canada

[5] St Michaels Hosp, Keenan Res Ctr Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada

[6] St Michaels Hosp, Glaucoma & Nerve Protect Unit, Toronto, ON M5B 1W8, Canada

来源：

SURVEY OF OPHTHALMOLOGY | 2007年 / 52卷

基金：

加拿大健康研究院;

关键词：

clinical neurophysiology; excitotoxicity; glaucoma; human; lateral geniculate nucleus; neuroiniaging; neuroprotection; optic nerve; oxidative injury; psychophysics; retinal ganglion cells; visual cortex;

D O I：

10.1016/j.survophthal.2007.08.006

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Elevated intraocular pressure in glaucoma can injure retinal ganglion cells and trigger the spread of disease to connected target vision structures of the brain. Glaucomatous degeneration has been observed in retrobulbar and intracranial optic nerve, lateral geniculate nucleus, and visual cortex of the brain. Oxidative damage and glutamate toxicity are implicated in transsynaptic central nervous system injury in glaucoma, similar to other neurodegenerative diseases. The perception of glaucoma as a disorder of "visual neurons" within the eye and brain may contribute to understanding progressive disease, and encourage comprehensive treatment strategies to prevent vision loss in glaucoma.

引用

页码：S122 / S126

页数：5

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