Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

被引：134
作者：
Petrie, HT [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Lab Dev Immunol, New York, NY 10021 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 11期
关键词：
D O I：
10.1038/nri1223
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Similar to all haematopoietic lineages, T cells must be replenished throughout life - a process that is the main function of the thymus. New progenitors are recruited to leave the bloodstream and enter the thymus, then to migrate in a defined pattern within the thymus during differentiation, and finally to return to the blood after maturation. Thereby, directional migration is intrinsically linked to all stages of T-cell differentiation. This review focuses on what is known and what is unknown about the signals that support this migration process in the mouse model of post-natal thymocyte differentiation.
引用
收藏
页码：859 / 866
页数：8
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