Immunopathology of psoriasis From bench to bedside

被引：10
作者：
de Masson, Adele [1 ,2 ,3 ]
Bouaziz, Jean-David [1 ,2 ,3 ]
Battistella, Maxime [2 ,4 ,5 ]
Bagot, Martine [1 ,2 ,3 ]
Bensussan, Armand [1 ,2 ,6 ]
机构：
[1] Hop St Louis, INSERM, U976, Lab Oncodermatol Immunol & Cellules Souches Cutan, 1 Ave Claude Vellefaux, F-75010 Paris, France
[2] Univ Paris 07, Sorbonne Paris Cite, Paris, France
[3] Hop St Louis, Serv Dermatol, 1 Ave Claude Vellefaux, F-75010 Paris, France
[4] Hop St Louis, Pathol Lab, 1 Ave Claude Vellefaux, F-75010 Paris, France
[5] Hop St Louis, INSERM, U1165, 1 Ave Claude Vellefaux, F-75010 Paris, France
[6] OREGA Biotech, 15 Chemin Saquin, F-69130 Ecully, France
来源：
M S-MEDECINE SCIENCES | 2016年 / 32卷 / 03期
关键词：
PLACEBO-CONTROLLED TRIAL; PLAQUE PSORIASIS; CELL POPULATION; DOUBLE-BLIND; AUTOIMMUNE INFLAMMATION; ADHESION MOLECULE-1; MONOCLONAL-ANTIBODY; GAMMA-INTERFERON; INTERLEUKIN; 22; TH17; CELLS;
D O I：
10.1051/medsci/20163203009
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Psoriasis is a frequent inflammatory disease that involves mostly the skin and sometimes the joints. This chronic disease is rarely life-threatening but impairs significantly the patient's quality of life. It is characterized, in its typical form, by erythematous and squamous plaques with well-defined borders, associated with increased proliferation of the keratinocytes, inflammation and greater number of dilated blood vessels in the upper dermis. A role of Th1 CD4 T cells was initially suspected. More recently, Th17 CD4 T cells have been shown to play a major role in the disease. It has led to the development of Th17 inhibitors, such as anti-IL-23 (cytokine that induces Th17 CD4 T cell differentiation), anti-IL-17, anti-IL-17RA (IL-17 receptor) and anti-IL-22 (cytokines that are notably produced by Th17 CD4 T cells). © 2016 médecine/sciences-Inserm.
引用
收藏
页码：253 / 259
页数：7
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