Self-assembly of calcium phosphate nanoparticles into hollow spheres induced by dissolved amino acids

被引：33

作者：

Hagmeyer, Daniel ^{[1
,2
]}

Ganesan, Kathirvel ^{[1
,2
]}

Ruesing, Johannes ^{[1
,2
]}

Schunk, Daniel ^{[2
,3
]}

Mayer, Christian ^{[2
,3
]}

Dey, Archan ^{[4
]}

Sommerdijk, Nico A. J. M. ^{[4
]}

Epple, Matthias ^{[1
,2
]}

机构：

[1] Univ Duisburg Essen, Inst Inorgan Chem, D-45117 Essen, Germany

[2] Univ Duisburg Essen, Ctr Nanointegrat Duisburg Essen CeNIDE, D-45117 Essen, Germany

[3] Univ Duisburg Essen, Inst Phys Chem, D-45117 Essen, Germany

[4] Eindhoven Univ Technol, NL-5600 MB Eindhoven, Netherlands

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2011年 / 21卷 / 25期

关键词：

ALPHA-BRASS; MICROSPHERES; DELIVERY; TRANSFORMATION; ORGANIZATION; HYDROXYAPATITE; FABRICATION; NANOSHELLS; DIFFUSION; SYSTEM;

D O I：

10.1039/c1jm11316j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Nanoparticles of calcium phosphate assemble spontaneously within a few seconds into hollow spheres with a diameter around 200-300 nm in the presence of dissolved amino acids and dipeptides. The process of formation was followed by cryo-transmission electron microscopy (cryoTEM), proving their hollow nature which was also confirmed by nano-indentation by atomic force microscopy (AFM). The hollow spheres were analyzed by scanning electron microscopy (SEM), dynamic light scattering (DLS), nanoparticle tracking analysis (NTA) and elemental analysis. The hollow spheres were moderately stable against heating and ultrasonication. A self-assembly of the primarily formed calcium phosphate nanoparticles around amino acid-rich domains in water is proposed. As this process was observed with different amino acids, it appears to be a more general phenomenon.

引用

页码：9219 / 9223

页数：5

共 41 条

[1]

ALEWOOD PF, 1983, SYNTHESIS-STUTTGART, P30

[2] Morphological and structural modifications of octacalcium phosphate induced by poly-L-aspartate [J].