Injury-activated glial cells promote wound healing of the adult skin in mice

被引：151

作者：

Parfejevs, Vadims ^{[1
,2
]}

Debbache, Julien ^{[1
]}

Shakhova, Olga ^{[3
]}

Schaefer, Simon M. ^{[1
]}

Glausch, Mareen ^{[1
]}

Wegner, Michael ^{[4
]}

Suter, Ueli ^{[5
]}

Riekstina, Una ^{[2
]}

Werner, Sabine ^{[5
]}

Sommer, Lukas ^{[1
]}

机构：

[1] Univ Zurich, Inst Anat, CH-8057 Zurich, Switzerland

[2] Univ Latvia, Fac Med, Raina Blvd, LV-1586 Riga, Latvia

[3] Univ Hosp Zurich, Dept Oncol, CH-8952 Schlieren, Switzerland

[4] Friedrich Alexander Univ Erlangen Nurnberg, Inst Biochem, D-91054 Erlangen, Germany

[5] ETH, Inst Mol Hlth Sci, CH-8093 Zurich, Switzerland

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

瑞士国家科学基金会;

关键词：

TRANSCRIPTION FACTOR SOX10; SCHWANN-CELLS; PERIPHERAL-NERVE; STEM-CELLS; MYELIN MAINTENANCE; SIGNALING PATHWAY; LIMB REGENERATION; SCIATIC-NERVE; IN-VIVO; C-JUN;

D O I：

10.1038/s41467-017-01488-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously associated with wound healing and promote myofibroblast differentiation by paracrine modulation of TGF-beta signalling. Accordingly, depletion of these cells impairs epithelial proliferation and wound closure through contraction, while their expansion promotes myofibroblast formation. Thus, injury-activated glia and/or their secretome might have therapeutic potential in human wound healing disorders.

引用

页数：16

共 69 条

[1] Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin [J].