Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine

被引：8

作者：

Bezdudny, Andrii V. ^{[1
,2
]}

Klukovsky, Denis ^{[1
,2
]}

Simurova, Natalia ^{[2
]}

Mykhailiuk, Pavel K. ^{[1
,3
]}

Shishkin, Oleg V. ^{[4
]}

Pustovit, Yurii M. ^{[1
,2
]}

机构：

[1] Enamine Ltd, UA-01103 Kiev, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev 94, Ukraine

[3] Kyiv Natl Taras Shevchenko Univ, Dept Chem, UA-01033 Kiev, Ukraine

[4] Natl Acad Sci Ukraine, Inst Single Crystals, STC, UA-61001 Kharkov, Ukraine

来源：

SYNTHESIS-STUTTGART | 2011年 / 01期

关键词：

fluorine; trifluoromethyl group; amines; cyclopropyl group; sulfur tetrafluoride; PRIVILEGED STRUCTURES; MEDICINAL CHEMISTRY; FLUORINE; DERIVATIVES; ACID; 3-(TRANS-2-NITROCYCLOPROPYL)ALANINE; PHARMACEUTICALS; CONSTITUENT;

D O I：

10.1055/s-0030-1258323

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(Trifluoromethyl)cyclopropanamine was synthesized. The key step of the synthesis is a transformation of the carboxy group into the trifluoromethyl group by using sulfur tetrafluoride. Twenty gram of the target product was conveniently prepared in a single batch.

引用

页码：119 / 122

页数：4

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