Desmosomes: Differentiation, development, dynamics and disease

被引：125
|
作者：
Garrod, D
Chidgey, M
North, A
机构：
[1] Epithelial Morphogenesis Res. Group, School of Biological Sciences, University of Manchester, Manchester M13 9PT, Oxford Road
来源：
CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0955-0674(96)80108-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate the adhesive properties of desmosomes in epithelial cell sheets. Genetic studies indicate the involvement of desmosomal components in cancer and epidermal diseases.
引用
收藏
页码：670 / 678
页数：9
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