Desmosomes: Differentiation, development, dynamics and disease

被引：125
作者：
Garrod, D
Chidgey, M
North, A
机构：
[1] Epithelial Morphogenesis Res. Group, School of Biological Sciences, University of Manchester, Manchester M13 9PT, Oxford Road
来源：
CURRENT OPINION IN CELL BIOLOGY | 1996年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0955-0674(96)80108-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recent evidence on the distribution of desmosomal glycoprotein isoforms that shows their combined expression in individual desmosomes has strengthened the belief that the latter are involved in epithelial differentiation and morphogenesis. It has been shown that cellular interactions and protein kinase C can modulate the adhesive properties of desmosomes in epithelial cell sheets. Genetic studies indicate the involvement of desmosomal components in cancer and epidermal diseases.
引用
收藏
页码：670 / 678
页数：9
相关论文
共 73 条
[1]   Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin [J].
Aberle, H ;
Schwartz, H ;
Hoschuetzky, H ;
Kemler, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1520-1526
[2]   THE HUMAN PLAKOGLOBIN GENE LOCALIZES ON CHROMOSOME 17Q21 AND IS SUBJECTED TO LOSS OF HETEROZYGOSITY IN BREAST AND OVARIAN CANCERS [J].
ABERLE, H ;
BIERKAMP, C ;
TORCHARD, D ;
SEROVA, O ;
WAGNER, T ;
NATT, E ;
WIRSCHING, J ;
HEIDKAMPER, C ;
MONTAGNA, M ;
LYNCH, HT ;
LENOIR, GM ;
SCHERER, G ;
FEUNTEUN, J ;
KEMLER, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6384-6388
[3]   Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation [J].
Allen, E ;
Yu, QC ;
Fuchs, E .
JOURNAL OF CELL BIOLOGY, 1996, 133 (06) :1367-1382
[4]   CONFORMATIONAL EPITOPES OF PEMPHIGUS ANTIGENS (DSG1 AND DSG3) ARE CALCIUM-DEPENDENT AND GLYCOSYLATION INDEPENDENT [J].
AMAGAI, M ;
ISHII, K ;
HASHIMOTO, T ;
GAMOU, S ;
SHIMIZU, N ;
NISHIKAWA, T .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 105 (02) :243-247
[5]   AUTOANTIBODIES AGAINST A NOVEL EPITHELIAL CADHERIN IN PEMPHIGUS-VULGARIS, A DISEASE OF CELL-ADHESION [J].
AMAGAI, M ;
KLAUSKOVTUN, V ;
STANLEY, JR .
CELL, 1991, 67 (05) :869-877
[6]   EXTRACELLULAR DOMAIN OF PEMPHIGUS-VULGARIS ANTIGEN (DESMOGLEIN-3) MEDIATES WEAK HEMOPHILIC ADHESION [J].
AMAGAI, M ;
KARPATI, S ;
KLAUSKOVTUN, V ;
UDEY, MC ;
STANLEY, JR .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 102 (04) :402-408
[7]   DELAYED ASSEMBLY OF DESMOSOMES IN KERATINOCYTES WITH DISRUPTED CLASSIC-CADHERIN-MEDIATED CELL-ADHESION BY A DOMINANT-NEGATIVE MUTANT [J].
AMAGAI, M ;
FUJIMORI, T ;
MASUNAGA, T ;
SHIMIZU, H ;
NISHIKAWA, T ;
SHIMIZU, N ;
TAKEICHI, M ;
HASHIMOTO, T .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (01) :27-32
[8]   ADHESION MOLECULES .1. KERATINOCYTE-GERATINOCYTE INTERACTIONS - CADHERINS AND PEMPHIGUS [J].
AMAGAI, M .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1995, 104 (01) :146-152
[9]   ASSIGNMENT OF THE HUMAN GENES FOR DESMOCOLLIN-3 (DSC3) AND DESMOCOLLIN-4 (DSC4) TO CHROMOSOME-18Q12 [J].
AMAGAI, M ;
WANG, YM ;
MINOSHIMA, S ;
KAWAMURA, K ;
GREEN, KJ ;
NISHIKAWA, T ;
SHIMIZU, N .
GENOMICS, 1995, 25 (01) :330-332
[10]  
ARNEMANN J, 1993, J CELL SCI, V104, P741
12345678