Large primary pulmonary synovial sarcoma successfully treated with pazopanib: a rare case report and literature review

Primary pulmonary synovial sarcoma (PPSS) is a rare spindle cell tumor derived from pulmonary mesenchymal tissue, accounting for 0.5% of all primary lung malignancies. Diagnosis is established after metastatic sarcoma or other primary lung malignancies have been excluded. This present study reports a rare case of a 19-year-old woman that presented with a large soft tissue mass filling the entire right thoracic cavity. Histopathological and immunohistochemical analysis confirmed this mass as pulmonary synovial sarcoma. The patient received pazopanib targeted therapy and is currently being followed up. Large PPSS tumors are rare with very few case reports in the literature. To the best of our knowledge, this present study is the first to report the successful treatment of PPSS with pazopanib.