Biomarkers for the diagnosis and monitoring of celiac disease: can you count on me?

被引:2
作者
Topa, Matilde [1 ,2 ]
Sanders, David Surendran [3 ,4 ]
Elli, Luca [1 ,2 ]
机构
[1] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy
[2] Fdn IRCCS CaGranda Osped Maggiore Policlin, Ctr Prevent & Diag Coeliac Dis, Gastroenterol & Endoscopy Unit, Milan, Italy
[3] Royal Hallamshire Hosp, Gastroenterol & Liver Unit, Sheffield, S Yorkshire, England
[4] Univ Sheffield, Sheffield, S Yorkshire, England
关键词
celiac disease; gluten-free diet monitoring; innovative molecular biomarkers; new endoscopic techniques; GLUTEN-FREE DIET; PERSISTENT VILLOUS ATROPHY; SMALL-BOWEL; CAPSULE ENDOSCOPY; TRANSGLUTAMINASE; ADHERENCE; PEPTIDES; SOCIETY; FOOD;
D O I
10.1097/MOG.0000000000000825
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Purpose of review Different markers are available to diagnose and monitor celiac disease (CeD); however, the concordance among them and their efficacy are still controversial. We aim at defining the efficacy of CeD biomarkers, their advantages and limits. Recent findings CeD diagnostic criteria are widely accepted, being a positive serology and duodenal atrophy (according to the Marsh-Oberhuber score) the main hallmarks. Flow cytometry and other molecular biomarkers support the diagnosis of refractory CeD. On the other side, CeD monitoring is less defined, as the biomarkers are not always reliable. To date, the reference standard to detect mucosal healing is represented by duodenal histology, but its timing and significance are debated. Novel scores may better define the trend of mucosal damage and MicroRNAs are among the innovative noninvasive biomarkers. The assessment of a correct gluten-free diet (GFD) is another aspect of CeD monitoring, based upon questionnaires and recently developed tools such as dosage of urinary or faecal gluten immunogenic peptides. Clinicians lack of a widely acknowledged tools to monitor CeD and GFD. Here, we present the efficacy of the most used markers.
引用
收藏
页码:263 / 269
页数:7
相关论文
共 41 条
  • [1] European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders
    Al-Toma, Abdulbaqi
    Volta, Umberto
    Auricchio, Renata
    Castillejo, Gemma
    Sanders, David S.
    Cellier, Christophe
    Mulder, Chris J.
    Lundin, Knut E. A.
    [J]. UNITED EUROPEAN GASTROENTEROLOGY JOURNAL, 2019, 7 (05) : 583 - 613
  • [2] Diagnostic Yield of Capsule Endoscopy in Refractory Celiac Disease
    Barret, Maximilien
    Malamut, Georgia
    Rahmi, Gabriel
    Samaha, Elia
    Edery, Joel
    Verkarre, Virginie
    Macintyre, Elizabeth
    Lenain, Emilie
    Chatellier, Gilles
    Cerf-Bensussan, Nadine
    Cellier, Christophe
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 (10) : 1546 - 1553
  • [3] A miRNA-Based Blood and Mucosal Approach for Detecting and Monitoring Celiac Disease
    Bascunan, Karla A.
    Perez-Bravo, Francisco
    Gaudioso, Gabriella
    Vaira, Valentina
    Roncoroni, Leda
    Elli, Luca
    Monguzzi, Erika
    Araya, Magdalena
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2020, 65 (07) : 1982 - 1991
  • [4] Diagnosis of coeliac disease by flow cytometry of intraepithelial lymphocytes: a new 'gold' standard?
    Basu, Kaninika
    Creasey, Hannah
    Bruggemann, Nina
    Stevens, Jennifer
    Bloxham, David
    Woodward, Jeremy Mark
    [J]. FRONTLINE GASTROENTEROLOGY, 2022, 13 (02) : 119 - 125
  • [5] A gluten-free diet score to evaluate dietary compliance in patients with coeliac disease
    Biagi, Federico
    Andrealli, Alida
    Bianchi, Paola Ilaria
    Marchese, Alessandra
    Klersy, Catherine
    Corazza, Gino Roberto
    [J]. BRITISH JOURNAL OF NUTRITION, 2009, 102 (06) : 882 - 887
  • [6] Gluten Immunogenic Peptides as Standard for the Evaluation of Potential Harmful Prolamin Content in Food and Human Specimen
    Cebolla, Angel
    de Lourdes Moreno, Maria
    Coto, Laura
    Sousa, Carolina
    [J]. NUTRIENTS, 2018, 10 (12):
  • [7] What is the Optimal Method Assessing for Persistent Villous Atrophy in Adult Coeliac Disease?
    Coleman, Sarah Helen
    Rej, Anupam
    Baggus, Elisabeth Megan Rose
    Lau, Michelle S.
    Marks, Lauren J.
    Hadjivassiliou, Marios
    Cross, Simon S.
    Leffler, Daniel A.
    Elli, Luca
    Sanders, David Surendran
    [J]. JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, 2021, 30 (02) : 205 - 212
  • [8] Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients
    Comino, Isabel
    Fernandez-Banares, Fernando
    Esteve, Maria
    Ortigosa, Luis
    Castillejo, Gemma
    Fambuena, Blanca
    Ribes-Koninckx, Carmen
    Sierra, Carlos
    Rodriguez-Herrera, Alfonso
    Carlos Salazar, Jose
    Caunedo, Angel
    Marugan-Miguelsanz, J. M.
    Antonio Garrote, Jose
    Vivas, Santiago
    lo lacono, Oreste
    Nunez, Alejandro
    Vaquero, Luis
    Maria Vegas, Ana
    Crespo, Laura
    Fernandez-Salazar, Luis
    Arranz, Eduardo
    Alejandra Jimenez-Garcia, Victoria
    Antonio Montes-Cano, Marco
    Espin, Beatriz
    Galera, Ana
    Valverde, Justo
    Jose Giron, Francisco
    Bolonio, Miguel
    Millan, Antonio
    Martinez Cerezo, Francesc
    Guajardo, Cesar
    Ramon Alberto, Jose
    Rosinach, Merce
    Segura, Veronica
    Leon, Francisco
    Marinich, Jorge
    Munoz-Suano, Alba
    Romero-Gomez, Manuel
    Cebolla, Angel
    Sousa, Carolina
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2016, 111 (10) : 1456 - 1465
  • [9] Coeliac disease
    Corazza, GR
    Villanacci, V
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 2005, 58 (06) : 573 - 574
  • [10] Identification of tissue transglutaminase as the autoantigen of celiac disease
    Dieterich, W
    Ehnis, T
    Bauer, M
    Donner, P
    Volta, U
    Riecken, EO
    Schuppan, D
    [J]. NATURE MEDICINE, 1997, 3 (07) : 797 - 801