Asymmetric accumulation of ASH1p in postanaphase nuclei depends on a myosin and restricts yeast mating-type switching to mother cells

被引:290
作者
Bobola, N
Jansen, RP
Shin, TH
Nasmyth, K
机构
[1] Res. Inst. of Molecular Pathology
关键词
D O I
10.1016/S0092-8674(00)81048-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell division in haploid yeast gives rise to a ''mother'' cell capable of mating-type switching and a ''daughter'' cell that is not. Switching is initiated by the HO endonuclease, whose gene is only transcribed in cells that have previously given birth to a bud (mother cells). HO expression depends on a minimyosin, She1p/Myo4p, which accumulates preferentially in growing buds. We describe a gene, ASH1, that is necessary to repress HO in daughters. ASH1 encodes a zinc finger protein whose preferential accumulation in daughter cell nuclei at the end of anaphase depends on She1p/Myo4p. The greater abundance of Ash1p in daughter cells is responsible for restricting HO expression to mother cells.
引用
收藏
页码:699 / 709
页数:11
相关论文
共 38 条
[1]   CLOSING THE CELL-CYCLE CIRCLE IN YEAST - G2 CYCLIN PROTEOLYSIS INITIATED AT MITOSIS PERSISTS UNTIL THE ACTIVATION OF G1 CYCLINS IN THE NEXT CYCLE [J].
AMON, A ;
IRNIGER, S ;
NASMYTH, K .
CELL, 1994, 77 (07) :1037-1050
[2]   CELL-CYCLE CONTROL OF THE YEAST HO GENE - CIS-ACTING AND TRANS-ACTING REGULATORS [J].
BREEDEN, L ;
NASMYTH, K .
CELL, 1987, 48 (03) :389-397
[3]  
CLARKLEWIS I, 1991, J BIOL CHEM, V266, P15180
[4]   EXPRESSION OF THE DAL80 GENE, WHOSE PRODUCT IS HOMOLOGOUS TO THE GATA FACTORS AND IS A NEGATIVE REGULATOR OF MULTIPLE NITROGEN CATABOLIC GENES IN SACCHAROMYCES-CEREVISIAE, IS SENSITIVE TO NITROGEN CATABOLITE REPRESSION [J].
CUNNINGHAM, TS ;
COOPER, TG .
MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (12) :6205-6215
[5]   STE20-LIKE PROTEIN-KINASES ARE REQUIRED FOR NORMAL LOCALIZATION OF CELL-GROWTH AND FOR CYTOKINESIS IN BUDDING YEAST [J].
CVRCKOVA, F ;
DEVIRGILIO, C ;
MANSER, E ;
PRINGLE, JR ;
NASMYTH, K .
GENES & DEVELOPMENT, 1995, 9 (15) :1817-1830
[6]   ROLES AND REGULATION OF CLN-CDC28 KINASES AT THE START OF THE CELL-CYCLE OF SACCHAROMYCES-CEREVISIAE [J].
DIRICK, L ;
BOHM, T ;
NASMYTH, K .
EMBO JOURNAL, 1995, 14 (19) :4803-4813
[7]   PARALLEL PATHWAYS OF GENE-REGULATION - HOMOLOGOUS REGULATORS SWI5 AND ACE2 DIFFERENTIALLY CONTROL TRANSCRIPTION OF HO AND CHITINASE [J].
DOHRMANN, PR ;
BUTLER, G ;
TAMAI, K ;
DORLAND, S ;
GREENE, JR ;
THIELE, DJ ;
STILLMAN, DJ .
GENES & DEVELOPMENT, 1992, 6 (01) :93-104
[8]   COMPLETE DNA-SEQUENCE OF YEAST CHROMOSOME-XI [J].
DUJON, B ;
ALEXANDRAKI, D ;
ANDRE, B ;
ANSORGE, W ;
BALADRON, V ;
BALLESTA, JPG ;
BANREVI, A ;
BOLLE, PA ;
BOLOTINFUKUHARA, M ;
BOSSIER, P ;
BOU, G ;
BOYER, J ;
BUITRAGO, MJ ;
CHERET, G ;
COLLEAUX, L ;
DALGNANFORNIER, B ;
DELREY, F ;
DION, C ;
DOMDEY, H ;
DUSTERHOFT, A ;
DUSTERHUS, S ;
ENTLAN, KD ;
ERFLE, H ;
ESTEBAN, PF ;
FELDMANN, H ;
FERNANDES, L ;
FOBO, GM ;
FRITZ, C ;
FUKUHARA, H ;
GABEL, C ;
GAILLON, L ;
CARCIACANTALEJO, JM ;
GARCIARAMIREZ, JJ ;
GENT, ME ;
GHAZVINI, M ;
GOFFEAU, A ;
GONZALEZ, A ;
GROTHUES, D ;
GUERREIRO, P ;
HEGEMANN, J ;
HEWITT, N ;
HILGER, F ;
HOLLENBERG, CP ;
HORAITIS, O ;
INDGE, KJ ;
JACQUIER, A ;
JAMES, CM ;
JAUNIAUX, JC ;
JIMENEZ, A ;
KEUCHEL, H .
NATURE, 1994, 369 (6479) :371-378
[9]   ISOLATION OF MONOCLONAL-ANTIBODIES SPECIFIC FOR HUMAN C-MYC PROTO-ONCOGENE PRODUCT [J].
EVAN, GI ;
LEWIS, GK ;
RAMSAY, G ;
BISHOP, JM .
MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (12) :3610-3616
[10]   THE ERYTHROID-SPECIFIC TRANSCRIPTION FACTOR ERYF1 - A NEW FINGER PROTEIN [J].
EVANS, T ;
FELSENFELD, G .
CELL, 1989, 58 (05) :877-885