Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

被引:27
作者
Marrone, Maria Cristina [1 ]
Coccurello, Roberto [2 ,3 ]
机构
[1] Fdn Rita Levi Montalcini, European Brain Res Inst EBRI, I-00161 Rome, Italy
[2] Natl Res Council CNR, Inst Complex Syst ISC, I-00185 Rome, Italy
[3] IRCCS S Lucia Fdn FSL, I-00143 Rome, Italy
关键词
microbiota-brain communication; dietary fatty acids; polyunsaturated fatty acids; depression; schizophrenia; HISTONE DEACETYLASE INHIBITORS; AUTISM SPECTRUM DISORDER; RESOLVING LIPID MEDIATORS; DEPRESSION-LIKE BEHAVIORS; IRRITABLE-BOWEL-SYNDROME; ANXIETY-LIKE BEHAVIOR; GUT MICROBIOTA; SODIUM-BUTYRATE; NEUROTROPHIC FACTOR; PROPIONIC-ACID;
D O I
10.3390/biom10010012
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gut-brain axis is a multimodal communication system along which immune, metabolic, autonomic, endocrine and enteric nervous signals can shape host physiology and determine liability, development and progression of a vast number of human diseases. Here, we broadly discussed the current knowledge about the either beneficial or deleterious impact of dietary fatty acids on microbiota-brain communication (MBC), and the multiple mechanisms by which different types of lipids can modify gut microbial ecosystem and contribute to the pathophysiology of major neuropsychiatric diseases (NPDs), such as schizophrenia (SCZ), depression and autism spectrum disorders (ASD).
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页数:29
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