RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders

被引：103

作者：

Iwamoto, K ^{[1
]}

Kato, T ^{[1
]}

机构：

[1] RIKEN, Lab Mol Dynam Mental Disorders, Brain Sci Inst, Wako, Saitama 3510198, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 346卷 / 03期

关键词：

serotonin 2C receptor; denaturing high performance liquid chromatography; bipolar disorder; major depression; schizophrenia; prefrontal cortex;

D O I：

10.1016/S0304-3940(03)00608-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The importance of serotonin 2C receptor (HTR2C) in mental disorders has been implicated by studies of HTR2C-deficient mice and linkage and association studies. Recent studies have revealed that RNA editing of HTR2C is involved in mental disorders. Here we examined RNA editing efficiencies of site A and D of HTR2C in the prefrontal cortex samples of patients with bipolar disorder, schizophrenia, and major depression as well as control subjects by using primer extension combined with denaturing high performance liquid chromatography. Postmortem samples were donated by the Stanley Foundation Brain Collection. We could not find significant alterations of RNA editing efficiencies of these sites in patients. However, we found trends for increased RNA editing efficiencies of site D in depressive patients (P = 0.08) and site A in suicide victims (P = 0.07). These findings are in accordance with the previous findings, and suggest that altered RNA editing of HTR2C may have some significance in major depression and suicide. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：169 / 172

页数：4

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