The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics

被引：148

作者：

Al Bitar, Samar ^{[1
,2
]}

Gali-Muhtasib, Hala ^{[1
,2
]}

机构：

[1] Amer Univ Beirut, Dept Biol, Beirut 1103, Lebanon

[2] Amer Univ Beirut, Ctr Drug Discovery, Beirut 1103, Lebanon

来源：

CANCERS | 2019年 / 11卷 / 10期

基金：

英国科研创新办公室;

关键词：

p21; signaling pathways; cell cycle; dual role; cancer therapy; chemoresistance; NUCLEOTIDE EXCISION-REPAIR; PROTEIN-PROTEIN INTERACTION; CELL-CYCLE; DNA-DAMAGE; C-MYC; P21; EXPRESSION; GROWTH ARREST; TRANSCRIPTIONAL REPRESSION; UBIQUITIN LIGASE; BREAST-CANCER;

D O I：

10.3390/cancers11101475

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

p21(cip1/waf1) mediates various biological activities by sensing and responding to multiple stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor suppressor mainly by inhibiting cell cycle progression and allowing DNA repair. Significant advances have been made in elucidating the potential role of p21 in promoting tumorigenesis. Here, we discuss the involvement of p21 in multiple signaling pathways, its dual role in cancer, and the importance of understanding its paradoxical functions for effectively designing therapeutic strategies that could selectively inhibit its oncogenic activities, override resistance to therapy and yet preserve its tumor suppressive functions.

引用

页数：21

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