Dissecting TLR3 signalling in dendritic cells

被引：35

作者：

Gauzzi, M. Cristina ^{[1
]}

Del Corno, Manuela ^{[1
]}

Gessani, Sandra ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

来源：

IMMUNOBIOLOGY | 2010年 / 215卷 / 9-10期

关键词：

Cytokines; Dendritic cells; Immune response; Interferon; Signalling pathway; TLR3; TOLL-LIKE RECEPTOR-3; DOUBLE-STRANDED-RNA; NF-KAPPA-B; INTERFERON REGULATORY FACTOR-3; INDUCED INTERLEUKIN-12P70 SECRETION; NATURAL-KILLER-CELLS; VIRAL-INFECTION; IFN-BETA; SUBCELLULAR-LOCALIZATION; DIFFERENTIAL EXPRESSION;

D O I：

10.1016/j.imbio.2010.05.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor (TLR) 3 recognizes double-stranded RNA and triggers the production of type 1 interferon and inflammatory cytokines/chemokines. Its engagement in dendritic cells (DCs) induces their maturation into potent immunostimulatory cells endowed with the capacity to efficiently cross-prime T lymphocytes. Owing to these properties, TLR3 agonists are currently under investigation as promising adjuvants in DC-based immunotherapy protocols for the treatment of viral and neoplastic diseases. Thus, a detailed understanding of the cascade of events specifically triggered in DCs upon engagement of this receptor is of great interest in translational research. In this review, we summarize the current knowledge on TLR3 signalling in DCs and highlight similarities and differences with respect to other cell types. (C) 2010 Elsevier GmbH. All rights reserved.

引用

页码：713 / 723

页数：11

共 107 条

[1] Dendritic cell (DC) based therapy for cervical cancer:: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C12U] (Ampligen®) [J].

Adams, M ;

Navabi, H ;

Jasani, B ;

Man, S ;

Fiander, A ;

Evans, AS ;

Donninger, C ;

Mason, M .

VACCINE, 2003, 21 (7-8) :787-790

[2] 1-methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity [J].

Agaugue, Sophie ;

Perrin-Cocon, Laure ;

Coutant, Frederic ;

Andre, Patrice ;

Lotteau, Vincent .

JOURNAL OF IMMUNOLOGY, 2006, 177 (04) :2061-2071

[3] Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells [J].

Akazawa, Takashi ;

Ebihara, Takashi ;

Okuno, Manabu ;

Okuda, Yu ;

Shingai, Masashi ;

Tsujimura, Kunio ;

Takahashi, Toshitada ;

Ikawa, Masahito ;

Okabe, Masaru ;

Inoue, Norimitsu ;

Okamoto-Tanaka, Miki ;

Ishizaki, Hiroyoshi ;

Miyoshi, Jun ;

Matsumoto, Misako ;

Seya, Tsukasa .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (01) :252-257

[4] Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4 [J].

Aksoy, E ;

Vanden Berghe, W ;

Detienne, S ;

Amraoui, Z ;

Fitzgerald, KA ;

Haegeman, G ;

Goldman, M ;

Willems, F .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2005, 35 (07) :2200-2209

[5] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[6] Not All Polyriboinosinic-polyribocytidylic Acids (Poly I:C) are Equivalent for Inducing Maturation of Dendritic Cells Implication for α-type-1 Polarized DCs [J].

Avril, Tony ;

de Tayrac, Marie ;

Leberre, Claudine ;

Quillien, Veronique .

JOURNAL OF IMMUNOTHERAPY, 2009, 32 (04) :353-362

[7]

Begon E, 2007, EUR J DERMATOL, V17, P497

[8] The molecular structure of the TLR3 extracellular domain [J].

Bell, Jessica K. ;

Botos, Istvan ;

Hall, Pamela R. ;

Askins, Janine ;

Shiloach, Joseph ;

Davies, David R. ;

Segal, David M. .

JOURNAL OF ENDOTOXIN RESEARCH, 2006, 12 (06) :375-378

[9] The molecular structure of the Toll-like receptor 3 ligand-binding domain [J].

Bell, JK ;

Botos, I ;

Hall, PR ;

Askins, J ;

Shiloach, J ;

Segal, DM ;

Davies, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (31) :10976-10980

[10] Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IκB kinase activity [J].

Bhattacharyya, S ;

Sen, P ;

Wallet, M ;

Long, B ;

Baldwin, AS ;

Tisch, R .

BLOOD, 2004, 104 (04) :1100-1109

← 1 2 3 4 5 6 7 8 9 10 →