EPR examination of free radical properties of DOPA-melanin complexes with ciprofloxacin, lomefloxacin, norfloxacin and sparfloxacin

被引：31
作者：
Beberok, Artur [1 ]
Buszman, Ewa [1 ]
Zdybel, Magdalena [2 ]
Pilawa, Barbara [2 ]
Wrzesniok, Dorota [1 ]
机构：
[1] Med Univ Silesia, Dept Pharmaceut Chem, Fac Pharm, PL-41200 Sosnowiec, Poland
[2] Med Univ Silesia, Dept Biophys, Fac Pharm, PL-41200 Sosnowiec, Poland
来源：
CHEMICAL PHYSICS LETTERS | 2010年 / 497卷 / 1-3期
关键词：
ELECTRON-SPIN-RESONANCE; ION BINDING-SITES; PARAMAGNETIC CENTERS; PIGMENT-EPITHELIUM; IN-VITRO; SPECTROSCOPY; MELANOCYTES; MELANOSOMES; TOXICITY; CELLS;
D O I：
10.1016/j.cplett.2010.07.079
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Paramagnetic complexes of DOPA-melanin with ciprofloxacin, lomefloxacin, norfloxacin and sparfloxacin were studied by EPR spectroscopy. The aim of this work was to determine free radical concentration and properties of these complexes. Free radical concentrations in the studied complexes were similar to 10(19)-10(20) spin/g. Relatively lower and similar (5.1-6.6 x 10(19) spin/g) free radical concentrations characterized DOPA-melanin complexes with ciprofloxacin, and lomefloxacin. Higher concentrations (0.8-1.2 x 10(20) spin/g) were obtained for complexes of norfloxacin and sparfloxacin. Effect of the drug concentration on free radicals in melanin was observed. Strong dipolar spin-spin interactions and slow spin-lattice relaxation processes exist in all of the samples. (C) 2010 Elsevier B.V. All rights reserved.
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收藏
页码：115 / 122
页数：8
相关论文
共 48 条
[1]   Photosensitizing potential of ciprofloxacin at ambient level of UV radiation [J].
Agrawal, Neeraj ;
Ray, Ratan Singh ;
Farooq, Mohammad ;
Pant, Aditya Bhushan ;
Hans, Rajendra Kumar .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2007, 83 (05) :1226-1236
[2]  
Belvedere A, 2002, PHOTOCHEM PHOTOBIOL, V76, P252, DOI 10.1562/0031-8655(2002)076<0252:PNDORA>2.0.CO
[3]  
2
[4]   UV-A induced oxidative stress is more prominent in naturally pigmented aged human RPE cells compared to non-pigmented human RPE cells independent of zinc treatment [J].
Biesemeier, Antje ;
Kokkinou, Despina ;
Julien, Sylvie ;
Heiduschka, Peter ;
Berneburg, Mark ;
Bartz-Schmidt, Karl Ulrich ;
Schraermeyer, Ulrich .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2008, 90 (02) :113-120
[5]   Electron spin resonance investigations of human retinal pigment epithelium melanosomes from young and old donors [J].
Bilinska, B ;
Pilawa, B ;
Zawada, Z ;
Wylegala, E ;
Wilczok, T ;
Dontsov, AE ;
Sakina, NL ;
Ostrovsky, MA ;
Ilyasova, VB .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2002, 58 (10) :2257-2264
[6]   STUDIES RELATED TO CHEMISTRY OF MELANINS .8. PYRROLECARBOXYLIC ACIDS FORMED BY OXIDATION OR HYDROLYSIS OF MELANINS DERIVED FROM 3,4-DIHYDROXYPHENETHYLAMINE OR (+/-)-3,4-DIHYDROXYPHENYLALANINE [J].
BINNS, F ;
CHAPMAN, RF ;
ROBSON, NC ;
SWAN, GA ;
WAGGOTT, A .
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1970, (08) :1128-&
[7]   Paramagnetic centers in DOPA-melanin-dihydrostreptomycin complexes [J].
Buszman, E ;
Pilawa, B ;
Zdybel, M ;
Wrzesniok, D ;
Grzegorczyk, A ;
Wilczok, T .
ACTA PHYSICA POLONICA A, 2005, 108 (02) :353-356
[8]   EPR examination of Zn2+ and Cu2+ effect on free radicals in DOPA-melanin-netilmicin complexes [J].
Buszman, E ;
Pilawa, B ;
Zdybel, M ;
Wrzesniok, D ;
Grzegorczyk, A ;
Wilczok, T .
CHEMICAL PHYSICS LETTERS, 2005, 403 (1-3) :22-28
[9]   EPR examination of Zn2+ and Cu2+ binding by pigmented soil fungi Cladosporium cladosporioides [J].
Buszman, Ewa ;
Pilawa, Barbara ;
Zdybel, Magdalena ;
Wilczynski, Slawomir ;
Gondzik, Anna ;
Witoszynska, Teresa ;
Wilczok, Tadeusz .
SCIENCE OF THE TOTAL ENVIRONMENT, 2006, 363 (1-3) :195-205
[10]   A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin, levofloxacin and sparfloxacin phototoxicity [J].
Dawe, RS ;
Ibbotson, SH ;
Sanderson, JB ;
Thomson, EM ;
Ferguson, J .
BRITISH JOURNAL OF DERMATOLOGY, 2003, 149 (06) :1232-1241
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