Synchronous Occurrence of Bazex Syndrome and Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome in a Patient with Lung Cancer

被引：8

作者：

Aoshima, Yoichiro ^{[1
]}

Karayama, Masato ^{[1
,2
]}

Sagisaka, Shinya ^{[3
]}

Yasui, Hideki ^{[1
]}

Hozumi, Hironao ^{[1
]}

Suzuki, Yuzo ^{[1
]}

Furuhashi, Kazuki ^{[1
]}

Enomoto, Noriyuki ^{[1
]}

Fujisawa, Tomoyuki ^{[1
]}

Nakamura, Yutaro ^{[1
]}

Inui, Naoki ^{[1
]}

Suda, Takafumi ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Internal Med 2, Hamamatsu, Shizuoka, Japan

[2] Hamamatsu Univ Sch Med, Dept Clin Oncol, Hamamatsu, Shizuoka, Japan

[3] Juzen Mem Hosp, Dept Resp Med, Hamamatsu, Shizuoka, Japan

来源：

INTERNAL MEDICINE | 2019年 / 58卷 / 22期

基金：

日本学术振兴会;

关键词：

Bazex syndrome; lung cancer; paraneoplastic syndrome; RS3PE syndrome; ACROKERATOSIS PARANEOPLASTICA; RS3PE; NIVOLUMAB; SAFETY;

D O I：

10.2169/internalmedicine.3032-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 69-year-old man developed bilateral polyarthritis, edematous extremities, and skin desquamation on the fingers and ears. He did not meet the criteria for any connective tissue disease, including rheumatoid arthritis. An examination revealed advanced lung cancer. His systemic manifestations were attributed to paraneoplastic Bazex syndrome and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. Treatment with pembrolizumab (an anti-programmed death-1 antibody) for lung cancer relieved his symptoms and shrank the lung tumor. Bazex and RS3PE syndromes are rare paraneoplastic diseases. We herein report this unique case of synchronous development of these two paraneoplastic syndromes in the presence of advanced lung cancer.

引用

页码：3267 / 3271

页数：5

共 19 条

[1] RS3PE syndrome presenting as vascular endothelial growth factor associated disorder [J].

Arima, K ;

Origuchi, T ;

Tamai, M ;

Iwanaga, N ;

Izumi, Y ;

Huang, M ;

Tanaka, F ;

Kamachi, M ;

Aratake, K ;

Nakamura, H ;

Ida, H ;

Uetani, M ;

Kawakami, A ;

Eguchi, K .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (11) :1653-1655

[2] ACROKERATOSIS PARANEOPLASTICA - A NEW CUTANEOUS MARKER OF MALIGNANCY [J].

BAZEX, A ;

GRIFFITHS, A .

BRITISH JOURNAL OF DERMATOLOGY, 1980, 103 (03) :301-306

[3] Patient selection for anti-PD-1/PD-L1 therapy in advanced non-small-cell lung cancer: implications for clinical practice [J].

Califano, Raffaele ;

Lal, Rohit ;

Lewanski, Conrad ;

Nicolson, Marianne C. ;

Ottensmeier, Christian H. ;

Popat, Sanjay ;

Hodgson, Matthew ;

Postmus, Pieter E. .

FUTURE ONCOLOGY, 2018, 14 (23) :2415-2431

[4] Clinical and pathologic findings of paraneoplastic dermatoses [J].

Chung, VQ ;

Moschella, SL ;

Zembowicz, A ;

Liu, V .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 54 (05) :745-762

[5] Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer [J].

Gettinger, Scott N. ;

Horn, Leora ;

Gandhi, Leena ;

Spigel, David R. ;

Antonia, Scott J. ;

Rizvi, Naiyer A. ;

Powderly, John D. ;

Heist, Rebecca S. ;

Carvajal, Richard D. ;

Jackman, David M. ;

Sequist, Lecia V. ;

Smith, David C. ;

Leming, Philip ;

Carbone, David P. ;

Pinder-Schenck, Mary C. ;

Topalian, Suzanne L. ;

Hodi, F. Stephen ;

Sosman, Jeffrey A. ;

Sznol, Mario ;

McDermott, David F. ;

Pardoll, Drew M. ;

Sankar, Vindira ;

Ahlers, Christoph M. ;

Salvati, Mark ;

Wigginton, Jon M. ;

Hellmann, Matthew D. ;

Kollia, Georgia D. ;

Gupta, Ashok K. ;

Brahmer, Julie R. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (18) :2004-U32

[6]

Hamanaka R, 2011, JPN J LUNG CANC, V51, P253

[7] Bazex Syndrome [J].

Iwanami, Keiichi ;

Nakai, Mori ;

Kitamura, Koichi .

INTERNAL MEDICINE, 2018, 57 (10) :1501-1502

[8] Paraneoplastic acrokeratosis of Bazex (Bazex's syndrome):: Report of a female case associated with cholangiocarcinoma and review of the published work [J].

Karabulut, Ayse Anil ;

Sahin, Sedef ;

Sahin, Muzaffer ;

Eksioglu, Meral ;

Ustun, Huseyin .

JOURNAL OF DERMATOLOGY, 2006, 33 (12) :850-854

[9] Safety of Programmed Death-1 Pathway Inhibitors Among Patients With Non-Small-Cell Lung Cancer and Preexisting Autoimmune Disorders [J].

Leonardi, Giulia C. ;

Gainor, Justin F. ;

Altan, Mehmet ;

Kravets, Sasha ;

Dahlberg, Suzanne E. ;

Gedmintas, Lydia ;

Azimi, Roxana ;

Rizvi, Hira ;

Riess, Jonathan W. ;

Hellmann, Matthew D. ;

Awad, Mark M. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (19) :1905-+

[10] Palmar fasciitis and polyarthritis syndrome-Systematic literature review of 100 cases [J].

Manger, Bernhard ;

Schett, Georg .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2014, 44 (01) :105-111

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