Endosomal Retrieval of Cargo: Retromer Is Not Alone

被引:100
作者
McNally, Kerrie E. [1 ]
Cullen, Peter J. [1 ]
机构
[1] Univ Bristol, Sch Biochem, Biomed Sci Bldg, Bristol BS8 1TD, Avon, England
基金
英国惠康基金;
关键词
HEREDITARY SPASTIC PARAPLEGIA; RECESSIVE INTELLECTUAL DISABILITY; WASH COMPLEX; SORTING RECEPTOR; MULTIPROTEIN COMPLEX; RETROGRADE TRANSPORT; HUMAN INTERACTOME; CANDIDATE GENE; COMMD PROTEINS; KIAA0196; GENE;
D O I
10.1016/j.tcb.2018.06.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Endosomes are major protein sorting stations in cells. Endosomally localised multi -protein complexes sort integral proteins, including signaling receptors, nutrient transporters, adhesion molecules, and lysosomal hydrolase receptors, for lysosomal degradation or conversely for retrieval and subsequent recycling to various membrane compartments. Correct endosomal sorting of these proteins is essential for maintaining cellular homeostasis, with defects in endosomal sorting implicated in various human pathologies including neurodegenerative disorders. Retromer, an ancient multi -protein complex, is essential for the retrieval and recycling of hundreds of transmembrane proteins. While retromer is a major player in endosomal retrieval and recycling, several studies have recently identified retrieval mechanisms that are independent of retromer. Here, we review endosomal retrieval complexes, with a focus on recently discovered retromer-independent mechanisms.
引用
收藏
页码:807 / 822
页数:16
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