Cytotoxic and antioxidant activities of diterpenes and sterols from the Vietnamese soft coral Lobophytum compactum

被引：21

作者：

Chau Van Minh ^{[1
]}

Phan Van Kiem ^{[1
]}

Nguyen Xuan Nhiem ^{[1
,2
]}

Nguyen Xuan Cuong ^{[1
]}

Nguyen Phuong Thao ^{[1
]}

Nguyen Hoai Nam ^{[1
]}

Hoang Le Tuan Anh ^{[1
]}

Do Cong Thung ^{[3
]}

Dinh Thi Thu Thuy ^{[4
]}

Kang, Hee-Kyoung ^{[5
]}

Jang, Hae-Dong ^{[6
]}

Kim, Young Ho ^{[2
]}

机构：

[1] VAST, Inst Marine Biochem, Hanoi, Vietnam

[2] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[3] VAST, Inst Marine Resources & Environm, Haiphong, Vietnam

[4] VAST, Inst Nat Prod Chem, Hanoi, Vietnam

[5] Cheju Natl Univ, Inst Med Sci, Sch Med, Cheju 690756, South Korea

[6] Hannam Univ, Dept Food & Nutr, Taejon 305811, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 07期

关键词：

Lobophytum compactum; Lobocompactol A; Lobocompactol B; Cytotoxic activity; Oxygen radical absorbance capacity;

D O I：

10.1016/j.bmcl.2011.01.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new diterpenes, lobocompactols A (1) and B (2), and five known compounds (3-7) were isolated from the methanol extract of the soft coral Lobophytum compactum using combined chromatographic methods and identified based on NMR and MS data. Each compound was evaluated for cytotoxic activity against A549 (lung) and HL-60 (acute promyelocytic leukemia) human cancer cell lines. Among them, compound 5 exhibited strong cytotoxic activity against the A549 cell line with an IC(50) of 4.97 +/- 0.06 mu M. Compounds 3, 4, and 7 showed moderate activity with IC(50) values of 23.03 +/- 0.76, 31.13 +/- 0.08, and 36.45 +/- 0.01 mu M, respectively. The cytotoxicity of 5 on the A549 cells was comparable to that of the positive control, mitoxantrone (MX). All compounds exhibited moderate cytotoxicity against the HL-60 cell line, with IC(50) values ranging from 17.80 +/- 1.43 to 59.06 +/- 2.31 mu M. Their antioxidant activity was also measured using oxygen radical absorbance capacity method, compounds 1 and 2 exhibiting moderate peroxyl radical scavenging activity of 1.4 and 1.3 mu M Trolox equivalents, respectively, at a concentration of 5 mu M. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2155 / 2159

页数：5

共 11 条

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