Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression

被引：132

作者：

Behl, Tapan ^{[1
]}

Rana, Tarapati ^{[1
,2
]}

Alotaibi, Ghallab H. ^{[3
]}

Shamsuzzaman, Md ^{[3
]}

Naqvi, Maaz ^{[4
]}

Sehgal, Aayush ^{[1
]}

Singh, Sukhbir ^{[1
]}

Sharma, Neelam ^{[1
]}

Almoshari, Yosif ^{[5
]}

Abdellatif, Ahmed A. H. ^{[6
,7
]}

Iqbal, Muhammad Shahid ^{[8
]}

Bhatia, Saurabh ^{[9
,10
]}

Al-Harrasi, Ahmed ^{[9
]}

Bungau, Simona ^{[11
]}

机构：

[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India

[2] Govt Pharm Coll, Mandi, Himachal Prades, India

[3] Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Shaqraa, Saudi Arabia

[4] Jamia Hamdard, Cent Res Lab, HIMSR, Dept Pharmacol, Delhi, India

[5] Jazan Univ, Coll Pharm, Dept Pharmaceut, Jazan, Saudi Arabia

[6] Qassim Univ, Coll Pharm, Dept Pharmaceut, Buraydah, Saudi Arabia

[7] Al Azhar Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, Assiut, Egypt

[8] Prince Sattam bin Abdulaziz Univ, Coll Pharm, Dept Clin Pharm, Alkharj, Saudi Arabia

[9] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman

[10] Univ Petr & Energy Studies, Sch Hlth Sci, Dehra Dun, Uttarakhand, India

[11] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea, Romania

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 146卷

关键词：

Oxidative stress; Depression; Antidepressants; Inflammation; Psychiatric disorders; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; MACROPHAGE CELL-LINE; MOLECULAR-MECHANISMS; MAJOR DEPRESSION; XANTHINE-OXIDASE; ARACHIDONIC-ACID; OLIVE OIL; ANTIDEPRESSANT TREATMENT;

D O I：

10.1016/j.biopha.2021.112545

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Depression is one of the most debilitating psychiatric disorders affecting people of all ages worldwide. Despite significant heterogeneity between studies, increased inflammation and oxidative stress have been found in depression. Oxidative stress and inflammation are involved in the pathogenesis of depression. In the current review, we discussed the markers of oxidative stress and inflammation in depressive disorder and the association between these markers and the antidepressant treatment. The role of natural polyphenols in regulating various cell signaling pathways related to oxidative stress and inflammation has also been reviewed. The inhibitory effect of polyphenols on several cell signaling pathways reveals the vital role of polyphenols in the prevention and treatment of depressive disorder. Understanding the mechanism of polyphenols implicated in the regulation of cell signaling pathways is essential for the identification of lead compounds and the development of novel effective compounds for the prevention and treatment of depressive disorder.

引用

页数：13

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