Significance of CD90+ cancer stem cells in human liver cancer

被引：1137
作者：
Yang, Zhen Fan [1 ,2 ]
Ho, David W. [1 ,2 ]
Ng, Michael N. [1 ,2 ]
Lau, Chi Keung [1 ,2 ]
Yu, Wan Ching [1 ,2 ]
Ngai, Patricia [1 ,2 ]
Chu, Patrick W. K. [1 ,2 ]
Lam, Chi Tat [1 ,2 ]
Poon, Ronnie T. P. [1 ,2 ]
Fan, Sheung Tat [1 ,2 ]
机构：
[1] Univ Hong Kong, Canc Res Ctr, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
来源：
CANCER CELL | 2008年 / 13卷 / 02期
关键词：
D O I：
10.1016/j.ccr.2008.01.013
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90(+) cells, but not the CD90(-) cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45(-)CD90(+) population, which could generate tumor nodules in immunodeficient mice. The CD90(+)CD44(+) cells demonstrated a more aggressive phenotype than the CD90(+)CD44(-) counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90(+) cells. Differential gene expression profiles were identified in the CD45(-)CD90(+) and CD45(-)CD90(-) cells isolated from tissue and blood samples from liver cancer patients and controls.
引用
收藏
页码：153 / 166
页数：14
相关论文
共 54 条
  • [1] Prospective identification of tumorigenic breast cancer cells
    Al-Hajj, M
    Wicha, MS
    Benito-Hernandez, A
    Morrison, SJ
    Clarke, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
  • [2] Alison MR, 2006, PANMINERVA MED, V48, P165
  • [3] Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: A retrospective and nationwide survey in Japan
    Arii, S
    Yamaoka, Y
    Futagawa, S
    Inoue, K
    Kobayashi, K
    Kojiro, M
    Makuuchi, M
    Nakamura, Y
    Okita, K
    Yamada, R
    [J]. HEPATOLOGY, 2000, 32 (06) : 1224 - 1229
  • [4] A long-term hepatitis B viremia model generated by transplanting nontumorigenic immortalized human hepatocytes in Rag-2-deficient mice
    Brown, JJ
    Parashar, B
    Moshage, H
    Tanaka, KE
    Engelhardt, D
    Rabbani, E
    Roy-Chowdhury, N
    Roy-Chowdhury, J
    [J]. HEPATOLOGY, 2000, 31 (01) : 173 - 181
  • [5] Bmi1 controls tumor development in an ink4a/Arf-independent manner in a mouse model for glioma
    Bruggeman, Sophia W. M.
    Hulsman, Danielle
    Tanger, Ellen
    Buckle, Tessa
    Blom, Marleen
    Zevenhoven, John
    van Tellingen, Olaf
    van Lohuizen, Maarten
    [J]. CANCER CELL, 2007, 12 (04) : 328 - 341
  • [6] Oct4 Targets Regulatory Nodes to Modulate Stem Cell Function
    Campbell, Pearl A.
    Perez-Iratxeta, Carolina
    Andrade-Navarro, Miguel A.
    Rudnicki, Michael A.
    [J]. PLOS ONE, 2007, 2 (06):
  • [7] Ceafalan L, 2005, Rev Med Chir Soc Med Nat Iasi, V109, P96
  • [8] Notch signaling in stem cell systems
    Chiba, Shigeru
    [J]. STEM CELLS, 2006, 24 (11) : 2437 - 2447
  • [9] CHO RW, 2007, IN PRESS STEM CELLS, V7
  • [10] Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: A systematic review
    Colli, A
    Fraquelli, M
    Casazza, G
    Massironi, S
    Colucci, A
    Conte, D
    Duca, P
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (03) : 513 - 523
123456