The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma

被引:4
作者
Aravind, Sithara [1 ]
Jose, Jasmin [1 ]
Shenoy, Praveen Kumar [2 ]
Avaronnan, Manuprasad [2 ]
Thavarool, Sajith Babu [3 ]
Nayanar, Sangeetha K. [1 ]
机构
[1] Malabar Canc Ctr, Div Oncopathol, Thalassery 670103, Kerala, India
[2] Malabar Canc Ctr, Div Med Oncol, Thalassery, Kerala, India
[3] Malabar Canc Ctr, Div Surg Oncol, Thalassery, Kerala, India
关键词
histomorphological changes; oral metronomic chemotherapy; oral squamous cell carcinoma; pathologic tumor response; NEOADJUVANT CHEMOTHERAPY; DEFINITIVE SURGERY; REGRESSION; NECK; HEAD; CANCERS; STAGE;
D O I
10.1055/s-0041-1735592
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Oral metronomic chemotherapy (OMCT) represents an emerging concept in cancer treatment involving frequent administration of chemotherapeutic drugs at doses below maximum tolerated doses and with no prolonged drug-free break. OMCT is being tried preoperatively in developing nations with constrained resources to prevent disease progression during the waiting period from diagnosis to surgery (bridge OMCT). The aim of the present study was to assess the spectrum of histomorphological changes and pathological tumor response following bridge OMCT in oral squamous cell carcinoma (OSCC) and to propose a new pathological response scoring system. Materials and Methods A retrospective single-center study comprised of tissue sections of tumor proper and metastatic lymph nodes of 50, locally advanced OSCC patients treated with bridge OMCT, and had completed definitive surgery were analyzed. The present study evaluated the histomorphological features and proposed a new scoring system for pathologic tumor response. The pathologic tumor response was categorized as complete response (pCR), no response (pNR), and partial response (pPR). Results Of the total 50 patients, 2 patients had pCR, 3 had pNR, and 45 patients had pPR as per the new proposed scoring system. Note that 96% of the cases showed no disease progression. Conclusion Bridge OMCT is a novel treatment method that can be used to tide over the waiting period between the diagnosis and surgery in resource-constrained institutions with heavy patient load. This mode of treatment in locally advanced OSCC seems to provide promising results in this setting. Large multicentric trials are warranted to confirm these results.
引用
收藏
页码:146 / 151
页数:6
相关论文
共 24 条
[1]   Metronomic Chemotherapy in Progressive Pediatric Malignancies: Old Drugs in New Package [J].
Bahl, Ankur ;
Bakhshi, Sameer .
INDIAN JOURNAL OF PEDIATRICS, 2012, 79 (12) :1617-1622
[2]  
Brandwein-Gensler A, 2005, AM J SURG PATHOL, V29, P167
[3]  
BRAUN OM, 1989, CANCER-AM CANCER SOC, V63, P1097, DOI 10.1002/1097-0142(19890315)63:6<1097::AID-CNCR2820630610>3.0.CO
[4]  
2-6
[5]   Consequence of neo-adjuvant chemotherapy on morphology of breast carcinoma: A systematic evaluation [J].
Chakrabarti, S. ;
Mandal, P. K. ;
Chowdhury, Roy A. ;
Das, S. .
INDIAN JOURNAL OF CANCER, 2016, 53 (01) :29-33
[6]   Head and neck cancer: metronomic chemotherapy [J].
De Felice, Francesca ;
Musio, Daniela ;
Tombolini, Vincenzo .
BMC CANCER, 2015, 15
[7]   Metronomic cyclophosphamide regimen selectively depletes CD4+ CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients [J].
Ghiringhelli, Francois ;
Menard, Cedric ;
Puig, Pierre Emmanuel ;
Ladoire, Sylvain ;
Roux, Stephan ;
Martin, Francois ;
Solary, Eric ;
Le Cesne, Axel ;
Zitvogel, Laurence ;
Chauffert, Bruno .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2007, 56 (05) :641-648
[8]   Prognostic importance of pathological response to neoadjuvant chemotherapy followed by definitive surgery in advanced oral squamous cell carcinoma [J].
Hirakawa, Hitoshi ;
Hanai, Nobuhiro ;
Suzuki, Hidenori ;
Nishikawa, Daisuke ;
Matayoshi, Sen ;
Hasegawa, Yasuhisa ;
Suzuki, Mikio .
JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 47 (11) :1038-1046
[9]   Prognostic impact of pathological response to neoadjuvant chemotherapy followed by definitive surgery in sinonasal squamous cell carcinoma [J].
Hirakawa, Hitoshi ;
Hanai, Nobuhiro ;
Ozawa, Taijiro ;
Suzuki, Hidenori ;
Nishikawa, Daisuke ;
Matayoshi, Sen ;
Suzuki, Mikio ;
Hasegawa, Yasuhisa .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016, 38 :E1305-E1311
[10]   Metronomic chemotherapy [J].
Maiti, Rituparna .
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS, 2014, 5 (03) :186-192