Evaluation of Serum Amyloid A Levels in Celiac Disease

被引:0
作者
Cakmak, Refika Yorulmaz [1 ]
Ekmen, Nergiz [2 ]
Kavutcu, Mustafa [3 ]
Gulbahar, Ozlem [3 ]
Arhan, Mehmet [2 ]
机构
[1] Mardin State Hosp, Clin Internal Med, Mardin, Turkey
[2] Gazi Univ, Dept Gastroenterol, Fac Med, Ankara, Turkey
[3] Gazi Univ, Dept Biochem, Fac Med, Ankara, Turkey
关键词
Celiac disease; serum amyloid A; C-reactive protein; RHEUMATOID-ARTHRITIS; A-PROTEIN; VITAMIN-D; RISK;
D O I
10.4274/BMJ.galenos.2021.32932
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: In celiac disease (CD), gluten intake triggers the release of T-cell-derived pro-inflammatory cytokines leading to an increase in the level of serum amyloid A (SAA). To confirm inflammation caused by CD in patients, SAA level is expected to be a better biomarker candidate than C-reactive protein (CRP). This study investigated the relationship between clinical and biochemical variables used in the follow-up of CD patients and SAA levels. Methods: This study is a cross-sectional observational study which was conducted in patients who presented with a diagnosis of CD in a university hospital between June 1, 2019 and December 1, 2019. Patients were categorized into two groups based on the presence of tissue transglutaminase (tTG) immunoglobulin. Statistical analysis of data was performed by considering the age, gender, duration of the disease, frequency of compliance with a gluten-free diet, body mass index, and some laboratory parameters [vitamin D (VD), tTG IgA-IgG, CRP] taken simultaneously with the SAA levels. Results: A total of 90 patients, 28 (31.1%) antibody positive and 62 (68.9%) antibody negative, were included in the study. We found out that there was a statistically significant difference between between SAA level, VD levels, and the duration of CD in the patients (p=0.03 and p=0.009, respectively). Conclusion: VD levels <20 ng/mL, in advanced age, and duration of CD >5 years should be evaluated in the high-risk groups in terms of high SAA levels. If there is a persistent increase in SAA level during follow-up visits of patients with CD, they should be evaluated in terms of complications caused by the chronic inflammation.
引用
收藏
页码:248 / 253
页数:6
相关论文
共 50 条
  • [31] Serum amyloid A levels in acute and chronic urticaria
    Lu, Wei
    Chen, Baobing
    Wang, Chunfeng
    Yang, Xiaohong
    Zhou, Changyu
    ANAIS BRASILEIROS DE DERMATOLOGIA, 2019, 94 (04) : 411 - 415
  • [32] Serum amyloid A levels in patients with liver diseases
    Zi-Ying Yuan
    Xing-Xin Zhang
    Yu-Jing Wu
    Zhi-Ping Zeng
    Wei-Min She
    Shi-Yao Chen
    Yuan-Qing Zhang
    Jin-Sheng Guo
    World Journal of Gastroenterology, 2019, 25 (43) : 6440 - 6450
  • [33] Serum amyloid A and haptoglobin levels in bovine amyloidosis
    Takahashi, Eiji
    Uzuka, Yuuji
    Tanabe, Sigeyuki
    Satoh, Motoyoshi
    Furuoka, Hidefumi
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 2007, 69 (03) : 321 - 323
  • [34] Evaluation of Zinc and Copper Levels in Sudanese Patients with Celiac disease in Red Sea State
    Idris, Haifa
    Elzein, Amnao M.
    Elxein, Husham O.
    PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, 2019, 13 (04): : 1120 - 1123
  • [35] Serum Markers in the Clinical Management of Celiac Disease
    Adriaanse, Marlou
    Leffler, Daniel A.
    DIGESTIVE DISEASES, 2015, 33 (02) : 236 - 243
  • [36] Association between serum amyloid A levels and coronary heart disease: a systematic review and meta-analysis of 26 studies
    Zhou, Jielin
    Lu, Yao
    Wang, Sufang
    Chen, Keyang
    INFLAMMATION RESEARCH, 2020, 69 (04) : 331 - 345
  • [37] Amino acid levels in children with celiac disease
    Sevinc, Eylem
    Akar, H. Haluk
    Sevinc, Nergiz
    Arslan, Duran
    Sezgin, Guelten C.
    Kendirci, Mustafa
    NUTRICION HOSPITALARIA, 2015, 32 (01) : 139 - 143
  • [38] Serum amyloid A as a marker of disease activity in Giant cell arteritis
    Dartevel, Anais
    Toussaint, Bertrand
    Trocme, Candice
    Arnaud, Melanie
    Simon, Nicolas
    Faure, Patrice
    Bouillet, Laurence
    AUTOIMMUNITY REVIEWS, 2020, 19 (01)
  • [39] Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis
    Li, Huan
    Xiang, Xiaochen
    Ren, Hongwei
    Xu, Lingli
    Zhao, Lisha
    Chen, Xiaoqiong
    Long, Hui
    Wang, Qiang
    Wu, Qingming
    JOURNAL OF INFECTION, 2020, 80 (06) : 646 - 655
  • [40] Serum cytokine elevations in celiac disease: Association with disease presentation
    Manavalan, John Sanil
    Hernandez, Lincoln
    Shah, Jayesh Girish
    Konikkara, John
    Naiyer, Afzal Jamal
    Lee, Anne Roland
    Ciaccio, Edward
    Minaya, Maria Theresa
    Green, Peter H. R.
    Bhagat, Govind
    HUMAN IMMUNOLOGY, 2010, 71 (01) : 50 - 57