Analysis of autophagy-related genes and associated noncoding RNAs and transcription factors in digestive system tumors

被引：4

作者：

Lin, Liewen ^{[3
]}

Xia, Ligang ^{[3
]}

Tang, Donge ^{[2
]}

Dai, Yong ^{[2
]}

Chen, Wenbiao ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Collaborat Innovat Ctr Diag & Treatment Infect Di, Coll Med,Natl Clin Res Ctr Infect Dis,State Key L, Hangzhou, Zhejiang, Peoples R China

[2] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Dept Clin Med R, Shenzhen 518020, Guangdong, Peoples R China

[3] Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Clin Med Coll 2,Shenzhen Peoples Hosp,Dept Gastro, Shenzhen 518020, Guangdong, Peoples R China

来源：

FUTURE ONCOLOGY | 2019年 / 15卷 / 36期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

autophagy-related gene; digestive system tumor; noncoding RNA; pan-cancer; transcription factor; INHIBITS AUTOPHAGY; CANCER STATISTICS; DATABASE; TUMORIGENESIS; PROTEIN; CELLS; NUPR1;

D O I：

10.2217/fon-2019-0341

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To investigate the autophagy-related gene (ATG) expression and the associated noncoding RNAs (ncRNA) and transcription factors (TF) in digestive system tumors (DST). Methods: We systematically investigated the ATG expression in DST by weighted gene correlation network analysis, crosstalk connection, functional analysis and Pivot analysis. Results: ATGs were clustered into six modules with co-expression in DST. Functional analysis revealed that six ATG-related modules were enriched in biological pathways involved in tumorigenesis. Pivot analysis identified key ncRNAs and TFs, which are essential for the pathogenesis, clinical diagnosis and treatment of DST. Conclusion: Our study highlights the crucial roles of ncRNA and TFs in the identification of potential biomarkers or therapeutic targets for DST.

引用

页码：4141 / 4154

页数：14

共 51 条

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