The TCF7L2 locus and type I diabetes

被引：17

作者：

Qu, Hui-Qi ^{[1
]}

Polychronakos, Constantin ^{[1
]}

机构：

[1] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Endocrine Genet Lab, Montreal, PQ H3H 1P3, Canada

来源：

BMC MEDICAL GENETICS | 2007年 / 8卷

关键词：

D O I：

10.1186/1471-2350-8-51

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion. This study aimed to investigate the possibility of genetic association between TCF7L2 and type 1 diabetes (T1D). Methods: The SNP most significantly associated with T2D, rs7903146, was genotyped in 886 T1D nuclear family trios with ethnic backgrounds of mixed European descent. Results: This study found no T1D association with, and no age-of-onset effect from rs7903146. Conclusion: This study suggests that a T2D mechanism mediated by TCF7L2 does not participate in the etiology of T1D.

引用

页数：5

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