Genomic Characterization of Campylobacter jejuni Strain M1

被引：74

作者：

Friis, Carsten ^{[1
]}

Wassenaar, Trudy M. ^{[2
]}

Javed, Muhammad A. ^{[3
]}

Snipen, Lars ^{[1
,4
]}

Lagesen, Karin ^{[1
,5
,6
]}

Hallin, Peter F. ^{[1
]}

Newell, Diane G. ^{[7
,8
]}

Toszeghy, Monique ^{[7
]}

Ridley, Anne ^{[7
]}

Manning, Georgina ^{[3
]}

Ussery, David W. ^{[1
]}

机构：

[1] Tech Univ Denmark, Dept Syst Biol, DK-2800 Lyngby, Denmark

[2] Mol Microbiol & Genom Consultants, Zotzenheim, Germany

[3] Nottingham Trent Univ, Sch Sci & Technol, Nottingham, England

[4] Norwegian Univ Life Sci, Dept Chem Biotechnol & Food Sci, As, Norway

[5] Oslo Univ Hosp, Inst Med Microbiol, Oslo, Norway

[6] Univ Oslo, Dept Informat, N-0316 Oslo, Norway

[7] Vet Labs Agencies, Addlestone, Surrey, England

[8] Food Borne Zoonoses Consultancy, Andover, England

来源：

PLOS ONE | 2010年 / 5卷 / 08期

关键词：

FRAGMENT-LENGTH-POLYMORPHISM; CLINICAL ISOLATE; SEQUENCE; PROTEIN; IDENTIFICATION; COLONIZATION; POULTRY; FIBRONECTIN; INFECTION; CHICKEN;

D O I：

10.1371/journal.pone.0012253

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Campylobacter jejuni strain M1 (laboratory designation 99/308) is a rarely documented case of direct transmission of C. jejuni from chicken to a person, resulting in enteritis. We have sequenced the genome of C. jejuni strain M1, and compared this to 12 other C. jejuni sequenced genomes currently publicly available. Compared to these, M1 is closest to strain 81116. Based on the 13 genome sequences, we have identified the C. jejuni pan-genome, as well as the core genome, the auxiliary genes, and genes unique between strains M1 and 81116. The pan-genome contains 2,427 gene families, whilst the core genome comprised 1,295 gene families, or about two-thirds of the gene content of the average of the sequenced C. jejuni genomes. Various comparison and visualization tools were applied to the 13 C. jejuni genome sequences, including a species pan- and core genome plot, a BLAST Matrix and a BLAST Atlas. Trees based on 16S rRNA sequences and on the total gene families in each genome are presented. The findings are discussed in the background of the proven virulence potential of M1.

引用

页数：12

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